Clinico-pathological profile of abdominal tuberculosis and their treatment response in a tertiary care centre

Authors

  • Rajani Mavila Department of Respiratory Medicine, Pariyaram Medical, College, Pariyaram, Kannur, Kerala, India
  • Manoj D. Kottarath Department of Respiratory Medicine, Pariyaram Medical, College, Pariyaram, Kannur, Kerala, India
  • Niyas Naseer Department of Respiratory Medicine, Pariyaram Medical, College, Pariyaram, Kannur, Kerala, India
  • Neethu Thambi Department of Respiratory Medicine, Pariyaram Medical, College, Pariyaram, Kannur, Kerala, India
  • Vinayak Mohan Department of Respiratory Medicine, Pariyaram Medical, College, Pariyaram, Kannur, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20164024

Keywords:

Abdominal tuberculosis, Abdominal pain, Histopathology

Abstract

Background: Abdominal tuberculosis is an important clinical entity having varied mode of clinical presentation. So the diagnosis of abdominal TB is difficult and careful approach to the patients and supportive investigation data are necessary to make the final diagnosis. Objectives of the study were to evaluate the clinic-pathological profile of patients with abdominal TB in a tertiary care centre in northern Kerala and to assess their response to anti-tubercular therapy under DOTS.

Methods: This was a retrospective follow up study conducted in the department of Pulmonary Medicine in association with the department of Gastro-medicine and Surgery, and medical college DOTS centre Pariyaram Medical College, Pariyaram Kannur district–Kerala, India. Total 55 patients with abdominal TB diagnosed on the basis of clinical profile and supported investigation data like gross morphological findings at endoscopy, colonoscopy, diagnostic laparoscopy, laparotomy or histologically proven caseating granulomas were selected for this study.

Results: Out of the 55 patients, 31 were males and 24 females with age ranging 16-80 (Mean 30.01±11.7) years. Abdominal pain was the most common presenting symptom in 45 (81.81%). The diagnosis of abdominal TB was confirmed histopathologically in 42 (76.36%). Remaining 13 (23.64%) cases were diagnosed microscopically and with supportive clinical and imaging background. All the patients were treated under DOTS.

Conclusions: Neither clinical features, laboratory, radiological and Endoscopic methods nor bacteriological and histopathological findings by themselves provide a gold standard in the diagnosis of abdominal TB. If diagnosed early, it can be treated successfully with anti-TB drugs.

References

Rosado E, Penha D, Paixao P, Costa AMD, Amadora PT. Abdominal tuberculosis - Imaging findings. Educational exhibit; ECR. 2013:C-0549. DOI :http://dx.doi.org/10.1594/ecr2013/C-0549

Tuberculosis Control In The South East Asia Annual Report 2016. http://www.searo.who.int/ tb/ annual-tb-report-2016.pdf?ua=1

Suri S, Gupta S, Suri R: Computed tomography in abdominal tuberculosis. Br J Radiol. 1999;92:92-8.

Mukewar S, Mukewar S, Ravi R, Prasad A, Dua KS. Colon tuberculosis: endoscopic features and prospective endoscopic follow-up after anti-tuberculosis treatment. Clin Transl Gastroenterol. 2012;3:e24.

Horvath KD, Whelan RL. Intestinal tuberculosis: return of an old disease. Am J Gastroenterol. 1998;93:692-6.

Akhan O, Pringot J. Imaging of abdominal tuberculosis. Eur Radiol. 2002;12:312-23.

Yunaev M, Ling A, Abbas S, Suen M, Pleass H. Abdominal tuberculosis: an easily forgotten diagnosis. ANZ J Surg. 2011;81(7-8):559-60.

McGuinness FE, Hamilton D, Al Nabulsi J. Tuberculosis of the gastrointestinal tract and peritoneum. In: McGuinness FE, editor. Clinical imaging of non-pulmonary tuberculosis. Berlin. Springer. 2000;107-38.

Hopewell PC. A clinical view of tuberculosis. Radiol Clin North Am. 1995;33:641-53.

Park K, Park’s textbook of Preventive & Social Medicine. 19th ed India M/S Banarasidas Bhanot. 2007: 768.

Kapoor VK, Abdominal tuberculosis. The Indian contribution. Indian J Gastroenterol. 1998;17:141-7.

Chalya PL, Mchembe MD, Mshana SE, Rambau PF, Jaka H, Mabula JB. Clinicopathological profile and surgical treatment of abdominal tuberculosis: a single centre experience in northwestern Tanzania. BMC Infectious Diseases. 2013;13:270.

Shaikh MS, Dholia KR, Jalbani MA. Prevalence of intestinal tuberculosis in cases of acute abdomen. Pakistan J Surg. 2007;23:52-6.

Butt T, Karamat KA, Ahmad RN, Mahmood A. Advances in diagnosis of tuberculosis. Pak J Pathol. 2001;12:1-3.

Lonnroth K, Raviglion M. Global epidemiology of tuberculosis: Prospects for control. Semin Respir Crit Care Med. 2008;29:481.

Rajpoot MJ, Memon AS, Rani S, Memon AH. Clinicopathological profile and surgical management outcomes in patients suffering from intestinal tuberculosis. J Liaqaut Uni Med Health Sci. 2005;4:113-8.

Skopin MS, Batyrov FA, Kornilova Z. The prevalence of abdominal tuberculosis and the specific features of its detection. Probl Tuberk Bolezn Legk. 2007;1:22-6.

Kapoor VK. Abdominal tuberculosis. Postgrad Med J. 1998;74:459-67.

Akbar M, Islam F, Haider IZ, Naveed D, Akbar I, Khattak I, et al. Surgical management of tuberculous small bowel obstruction. J Ayub Med Coll Abbottabad. 2010;22:171-5.

Khan R, Abid S, Jafri W, Abbas Z, Hameed K, Ahmad Z. Diagnostic dilemma of abdominal tuberculosis in non-HIV patients: An ongoing challenge for physicians. World J Gastroenterol. 2006;12:6371-5.

Palmer KR, Patil DH, Basran GS, Riordan JF, Silk DB. Abdominal tuberculosis in urban Britain–a common disease. Gut. 1985;26:1296-13.

Marshall JB, Tuberculosis of the gastrointestinal tract and peritoneum Am J Gastroenterol. 199388:989-99.

Bhansali SK. Abdominal tuberculosis. Experiences with 300 cases. Am J Gastroenterol. 1977;67:324-37.

Paustian FF, Marshall JB, Intestinal tuberculosis. In: Berk JE, editor Bockus Gastroenterology 1985, 4th ed Philadelphia WB Saunders. 2018-36.

Hoon JR, Dockerty MB, Pemberton J. Ileocaecal tuberculosis including a comparison of this disease with non-specific regional enterocolitis and noncaseous tuberculated enterocolitis. Int Abstr Surg. 1950;91:417-40.

Baloch NA, Baloch MA, Baloch FA. A study of 86 cases of abdominal tuberculosis. J Surg Pak. 2008;13:30-2.

Sharma MP, Bhatia V. Abdominal tuberculosis. Indian J Med Res. 2004;120:305-15.

Arif AU, Shah LA, Ullah A, Sadiq Mu D. The frequency and management of intestinal tuberculosis; a hospital based study. J Postgrad Med Instit. 2008;22(2):152-6.

Downloads

Published

2016-12-16

How to Cite

Mavila, R., Kottarath, M. D., Naseer, N., Thambi, N., & Mohan, V. (2016). Clinico-pathological profile of abdominal tuberculosis and their treatment response in a tertiary care centre. International Journal of Research in Medical Sciences, 4(12), 5120–5124. https://doi.org/10.18203/2320-6012.ijrms20164024

Issue

Section

Original Research Articles