The influence of n-[imino(1-piperidinyl)methyl]guanidine and n-[imino(4-morpholinyl)methyl]guanidine on citrate content,aconitase and citrate synthase activities at ischemia-reperfusionof rats brain
The influence of some guanidine derivatives on the level of brain citrate, brain activities of aconitase and citrate synthase has been investigated in rats subjected to ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Treatment with these compounds also decreased the degree of DNA fragmentation markedly increased in rats with ischemia-reperfusion.
Sukhoveeva O.V., Popova T.N., Makeeva A.V., Iskusnykh I.Yu. (2011) The influence of n-[imino(1-piperidinyl)methyl]guanidine and n-[imino(4-morpholinyl)methyl]guanidine on citrate content,aconitase and citrate synthase activities at ischemia-reperfusionof rats brain. Biomeditsinskaya Khimiya, 57(5), 519-525.
Sukhoveeva O.V. et al. The influence of n-[imino(1-piperidinyl)methyl]guanidine and n-[imino(4-morpholinyl)methyl]guanidine on citrate content,aconitase and citrate synthase activities at ischemia-reperfusionof rats brain // Biomeditsinskaya Khimiya. - 2011. - V. 57. -N 5. - P. 519-525.
Sukhoveeva O.V. et al., "The influence of n-[imino(1-piperidinyl)methyl]guanidine and n-[imino(4-morpholinyl)methyl]guanidine on citrate content,aconitase and citrate synthase activities at ischemia-reperfusionof rats brain." Biomeditsinskaya Khimiya 57.5 (2011): 519-525.
Sukhoveeva, O. V., Popova, T. N., Makeeva, A. V., Iskusnykh, I. Yu. (2011). The influence of n-[imino(1-piperidinyl)methyl]guanidine and n-[imino(4-morpholinyl)methyl]guanidine on citrate content,aconitase and citrate synthase activities at ischemia-reperfusionof rats brain. Biomeditsinskaya Khimiya, 57(5), 519-525.
