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Microwave Assisted Synthesis, Spectral Studies and Antimicrobial Activities of some 2′,4′-Difluorophenyl Chalcones

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Abstract:

Some 2′,4′-difluorophenyl chalcones have been synthesized under microwave irradiation using aldol condensation between 2,4-difluoroacetophenone and substituted benzaldehydes using catalytic amount of hydroxyapatite. The yields of the chalcones are more than 85%. The purities of these synthesized chalcones were examined by their physical constants and spectroscopic data. The UV absorption maxima (λmax, nm), infrared stretches (ν, cm-1) of CO, fingerprint region of CHip/op, CH=CHop, C=Cop modes, NMR chemical shifts (δ, ppm) of vinyl proton, carbon and carbonyl carbons have been assigned and correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the statistical analysis the effect of substituent on the above spectral frequencies can be discussed. The antimicrobial activities of these synthesized chalcones have been screened using Bauer-Kirby method.

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Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 14)

Pages:

68-86

DOI:

https://doi.org/10.56431/p-v23467

Citation:

Cite this paper

Online since:

May 2013

Authors:

S. Vijayakumar, R. Arulkumaran, R. Sundararajan, S.P. Sakthinathan, R. Suresh, D. Kamalakkannan, K. Ranganathan, K. Sathiyamoorthy, V. Mala, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan

Keywords:

Aldol Condensation, Antimicrobial Activities, Hammett σ Constants, Hydroxyapatite, Microwave Irradiation, Spectral Correlations

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