Objective: A working group (WG) of the Japanese Society of Nuclear Cardiology (JSNC) determined Japanese normal databases of myocardial perfusion single-photon emission computed tomography (SPECT) on semi-conductor gamma camera (D-SPECT), and the aim of this study was to validate its clinical utility.
Materials and methods: The normal myocardial perfusion SPECT (MPS) databases of Japanese patients in the ²⁰¹Tl stress/redistribution protocol (²⁰¹Tl protocol), ^99mTc stress/rest or rest/stress protocol (^99mTc protocol), and rest ^99mTc/stress ²⁰¹Tl simultaneous acquisition dual-isotope protocol (SDI protocol) were created by JSNC WG. The WG collected clinical cases for the ²⁰¹Tl protocol (male/female [m/f], 8/8), ^99mTc protocol (m/f, 9/7), and SDI protocol (m/f, 10/10) from WG participating hospitals. Four WG members read those clinical cases on a 17-segment and 5-point scale (0–4). Using the most frequent values as the score for each segment, weighted κ values were calculated with the scores obtained from quantitative perfusion software (QPS).
Results: Weighted κ values were as follows; ²⁰¹Tl stress/female, 0.77; ²⁰¹Tl rest/female, 0.74; ²⁰¹Tl stress/male, 0.81; ²⁰¹Tl rest/male, 0.68; ^99mTc stress/female, 0.77; ^99mTc rest/female, 0.62; ^99mTc stress/male, 0.77; ^99mTc rest/male, 0.75; SDI stress/female, 0.87; SDI rest/female, 0.82; SDI stress/male, 0.87; SDI rest/male, 0.85.
Conclusions: The diagnostic accuracy of Japanese MPS normal databases on D-SPECT were comparable with nuclear cardiology expert reading and further clinical applications are expected.