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Clozapine treatment and risk of COVID-19.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Lewis, Jonathan 
Khandaker, Golam M 

Abstract

The antipsychotic clozapine is known to have immune-modulating effects. Clozapine treatment has been reported to be associated with increased risk of COVID-19 infection. However, it remains unclear whether this is because of increased testing of this patient group, who are closely monitored. We linked anonymised health records from mental health services in Cambridgeshire (UK), for patients taking antipsychotic medication, with data from the local COVID-19 testing hub. Patients receiving clozapine were more likely to be tested for COVID-19, but not to test positive. Increased testing in patients receiving clozapine suggests prudent judgement by clinicians, considering the overall health vulnerabilities of this group.

Description

Keywords

Antipsychotics, COVID-19, clozapine, psychotic disorders, schizophrenia

Journal Title

BJPsych Open

Conference Name

Journal ISSN

2056-4724
2056-4724

Volume Title

8

Publisher

Royal College of Psychiatrists
Sponsorship
Wellcome Trust (201486/Z/16/Z)
Medical Research Council (MC_PC_17213)
MQ: Transforming Mental Health (MQDS17\40)
Medical Research Council (MR/S037675/1)
National Institute for Health Research (IS-BRC-1215-20014)
MRC (via Swansea University) (DATAMIND 106893)