Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines
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Peer-reviewed
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Article
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Abstract
Catalytic synthesis of nonracemic P-chiral phosphine derivatives remains a significant challenge. Here we report Cu-catalyzed enantioselective arylation of secondary phosphine oxides with diaryliodonium salts for the synthesis of tertiary phosphine oxides with high enantiomeric excess. The new process is demonstrated on a wide range of substrates and leads to products that are well-established P-chiral catalysts and ligands.
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0305 Organic Chemistry
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Journal of the American Chemical Society
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0002-7863
1520-5126
1520-5126
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138
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Amercian Chemical Society
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European Research Council (259711)
Engineering and Physical Sciences Research Council (EP/I00548X/1)
Engineering and Physical Sciences Research Council (EP/I00548X/1)
We are grateful to the European Commission for a Marie Curie International Outgoing Fellowship (R.J.P.), the ERC (R.B.), the EPSRC, and the Royal Society (M.J.G.) for fellowships. Mass spectrometry data were acquired at the EPSRC UK National Mass Spectrometry Facility at Swansea University.