Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
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Abstract: Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.
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Funder: NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024)
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RCUK | Medical Research Council (MRC) (G0701120, G1001245, MR/M013111/1, MR/R024065/1, MR/L003120/1, G0701120, G1001245, MR/M013111/1, MR/R024065/1, MR/K026992/1)
British Heart Foundation (BHF) (SP/09/002, RG/13/13/30194, RG/18/13/33946)