In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR
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Non-enzymatic glycation of extracellular matrix with (U-13C5)-Dribose- 5-phosphate (R5P), enables in situ 2D ssNMR identification of many deleterious protein modifications and crosslinks, including previously unreported oxalamido and hemiaminal (CH3- CH(OH)NHR) substructures. Changes in charged residue proportions and distribution may be as important as crosslinking in provoking and understanding harmful tissue changes.
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Chemical Communications
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RSC
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Medical Research Council (MR/M01066X/1)
EPSRC (1235152)
Medical Research Council (MR/J007692/1)
EPSRC (1235152)
Medical Research Council (MR/J007692/1)