Zinc(II) Complexes Derived from Schiff Bases: Syntheses, Structures, and Biological Activity

Abstract

Three new zinc(II) complexes, [Zn₂I₂(L¹)₂] (1), [Zn(HL²)₂(NCS)₂] (2), and [ZnIL³] (3), where L¹ is the anionic form of 2-[(6-methylpyridin-2-ylimino)methyl]phenol (HL¹), HL² is the zwitterionic form of 2-(cyclopropyliminomethyl)-5-fluorophenol (HL²), and L³ is the anionic form of 5-bromo-2-[(3-morpholin-4-ylpropylimino)methyl]phenol (HL³), have been prepared and characterized by elemental analyses, IR, UV and NMR spectra, and single crystal X-ray crystallographic determination. Complex 1 is a dinuclear zinc complex, and complexes 2 and 3 are mononuclear zinc complexes. The Zn atoms in the complexes are in tetrahedral coordination. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans were evaluated.