Synthesis and Biological Evaluation of Some Novel 1,8-Naphthyridine Derivatives
DOI:
https://doi.org/10.17344/acsi.2017.3617Keywords:
1, 8-Naphthyridine, Quinazolone, Pyrazole, Cytotoxicity, AntioxidantAbstract
A series of substituted 1,8-naphthyridine derivatives was synthesized to be used as cytotoxic and antioxidant agents by applying 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carbohydrazide (1) as the starting material. Compound 1 was reacted with different reagents to afford the corresponding 3-heterarylcarbonyl-1,8-naphthyridine derivatives 3–19 which were tested for their in vitro cytotoxicity against Ehrlich Ascites Carcinoma, and antioxidant activity. Compound 15 showed the best cytotoxicity and antioxidant activity.
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Published
12.12.2017
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Organic chemistry
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