Year 2017 / Volume 109 / Number 9
Letter to the Editor
A case of a mixed adenoneuroendocrine tumor of the colon

673

DOI: 10.17235/reed.2017.5008/2017

Joana Ribeiro da Silva, Rolando Taveira Pinho, Antonia Furtado,

Abstract
Neuroendocrine cells often coexist with exocrine neoplasms of the gut and each component is normally present in a variable range. Despite this frequent association, mixed exocrine-neuroendocrine carcinomas are rare. This entity is known as adenoneuroendocrine carcinoma (MANEC) and each of its malignant components represents at least 30%. In contrast, there are only a few reports of another rare association of an adenoma and a well differentiated neuroendocrine tumor (NET) in the colon and rectum. The term mixed adenoneuroendocrine tumor (MANET) was suggested due to its indolent behavior and distinct morphological characteristics with mild to moderate nuclear atypia and low number of mitoses1. However, it is not included in the recent World Health Organization (WHO) classification of tumors of the digestive system.
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References
REFERENCES
1.Nair M. Composite carcinoma of the colon: A case report with literature review. Journal of Oncology [serial online]. 2007; Volume 5, Number 2.
2. Rosa SL, Marando A, Furlan D, et al. Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: Insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers. Am J Surg Pathol. 2012; 36: 601--611
3.Varghese NM, Zaitoun AM, Thomas SM, et al. Composite glandular-carcinoid tumour of the terminal ileum. J. Clin.Pathol. 1994; 47: 427--429.
4. Rosa S, Marando A, Sessa F, et al. Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update. Cancers. 2012; 4: 11--30.
5. Rindi G. Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F,eds. WHO Classification of Tumours of the Digestive System. France; 2010: 13–14.
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Silva J, Pinho R, Furtado A. A case of a mixed adenoneuroendocrine tumor of the colon. 5008/2017


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Publication history

Received: 13/04/2017

Accepted: 21/04/2017

Online First: 04/08/2017

Published: 31/08/2017

Article Online First time: 113 days

Article editing time: 140 days


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