The rare plants and unusual wetland communities of Canaan Valley are potentially threatened by establishment of exotic and invasive plants. We consulted various references and assembled a list of 106 invasive and/or exotic plant species that have been found growing in Canaan Valley; the most speciose families are Poaceae (grasses), Fabaceae (legumes), and Asteraceae (sunflowers). We recommend that diverse local stakeholders cooperate to plan and implement a program to prevent the establishment of highly invasive plants in Canaan Valley.