Abstract
Autophagy is a conserved catabolic process characterized by degradation and recycling of cytosolic components or organelles through a lysosome-dependent pathway. It has a complex and close relationship to drug resistance in breast cancer. MicroRNAs (miRNAs) are small noncoding molecules that can influence numerous cellular processes including autophagy, through the posttranscriptional regulation of gene expression. Autophagy is regulated by many proteins and pathways, some of which in turn have been found to be regulated by miRNAs. These miRNAs may affect the drug resistance of breast cancer. Drug resistance is the main cause of distant recurrence, metastasis and death in breast cancer patients. In this review, we summarize the causative relationship between autophagy and drug resistance of breast cancer. The roles of autophagy-related proteins and pathways and their associated miRNAs in drug resistance of breast cancer are also discussed.
概要
自噬是一种保守的分解代谢过程, 其特征在于通过溶酶体依赖性途径降解和再循环胞质成分或细胞器. 它与乳腺癌的耐药性有着复杂而密切的关系. 小分子核糖核酸 (microRNA,miRNA) 是小的非编码分子, 可通过基因表达的转录后调控来影响众多细胞过程, 包括自噬. 许多蛋白质和途径能调节自噬, 而其中一些反过来又被 miRNA 调节. 另外, 这些miRNA 可能会影响乳腺癌的耐药性. 耐药性是乳腺癌患者远处复发, 转移和死亡的主要原因. 在这篇综述中, 我们总结了乳腺癌自噬与药物耐药性之间的因果关系, 同时还讨论了自噬相关蛋白和途径及其相关的 miRNA 在乳腺癌耐药性中的作用.
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Zheng-gui DU contributed to the conception of the article. Nan WEN wrote and edited the manuscript and created the figures. Qing LV edited and checked the final version. All authors participated in manuscript revision, and have read and approved the final version.
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Nan WEN, Qing LV, and Zheng-gui DU declare that they have no conflict of interest.
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Project supported by the Department of Science and Technology of Sichuan Province, China (No. 2019YFH0146) and the Health Commission of Sichuan Province, China (Research Project on Healthcare in Sichuan Province, No. 2019-107)
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Wen, N., Lv, Q. & Du, Zg. MicroRNAs involved in drug resistance of breast cancer by regulating autophagy. J. Zhejiang Univ. Sci. B 21, 690–702 (2020). https://doi.org/10.1631/jzus.B2000076
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DOI: https://doi.org/10.1631/jzus.B2000076