Abstract
Objective
To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning.
Methods
A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented.
Results
Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up.
Conclusions
Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.
Similar content being viewed by others
References
Bartlett, J., Brunner, M., Gough, K., 2010. Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill. Emerg. Med. J., 27(2):159–160. [doi:10.1136/emj.2008.069401]
Blanck, H.M., Serdula, M.K., Gillespie, C., Galuska, D.A., Sharpe, P.A., Conway, J.M., Khan, L.K., Ainsworth, B.E., 2007. Use of nonprescription dietary supplements for weight loss is common among Americans. J. Am. Diet. Assoc., 107(3):441–447. [doi:10.1016/j.jada.2006.12.009]
Descatha, A., Mégarbane, B., Garcia, V., Baud, F., 2009. Delayed immunosuppressive treatment in life-threatening paraquat ingestion: a case report. J. Med. Toxicol., 5(2): 76–79. [doi:10.1007/BF03161092]
Fertel, B.S., Nelson, L.S., Goldfarb, D.S., 2010. Extracorporeal removal techniques for the poisoned patient: a review for the intensivist. J. Intensive Care Med., 25(3):139–148. [doi:10.1177/0885066609359592]
Kang, M.S., Gil, H.W., Yang, J.O., Lee, E.Y., Hong, S.Y., 2009. Comparison between kidney and hemoperfusion for paraquat elimination. J. Korean Med. Sci., 24(Suppl. 1): S156–S160. [doi:10.3346/jkms.2009.24.S1.S156]
Kurt, T.L., Anderson, R., Petty, C., Bost, R., Reed, G., Holland, J., 1986. Dinitrophenol in weight loss: the poison centre and public health safety. Vet. Hum. Toxicol., 28(6): 574–575.
McFee, R.B., Caraccio, T.R., McGuigan, M.A., Reynolds, S.A., Bellanger, P., 2004. Dying to be thin: a dinitrophenol related fatality. Vet. Hum. Toxicol., 46(5):251–254.
Ray, S., Peters, C.A., 2008. Changes in microbiological metabolism under chemical stress. Chemosphere, 71(3):474–483. [doi:10.1016/j.chemosphere.2007.10.026]
Tainter, M.L., Cutting, W.C., Stockton, A.B., 1934. Use of dinitrophenol in nutritional disorders: a critical survey of clinical results. Am. J. Public Health, 24(10):1045–1053. [doi:10.2105/AJPH.24.10.1045]
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lu, Yq., Jiang, Jk. & Huang, Wd. Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning. J. Zhejiang Univ. Sci. B 12, 189–192 (2011). https://doi.org/10.1631/jzus.B1000265
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1631/jzus.B1000265