Abstract
Adenomas of the nonpigmented ciliary epithelium (NPCE) are often clinically indistinguishable from amelanotic malignant melanomas of the ciliary body or metastatic carcinomas. This paper reports a case study of a distinctive variant of adenoma of the NPCE, which clinically appears as epiretinal membrane in the macular region. Histopathologic studies have revealed this is an adenoma of the NPCE. Identification of this clinic feature is important because it will miss the diagnosis of the adenoma of the NPCE. In this case study, B-scan ultrasonography as well as computerized tomography (CT) has been used to provide help in diagnosing the ciliary body tumor. Because of their anterior location in the ciliary body, partial lamellar sclerouvectomy is an effective method of treatment.
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References
Biswas, J., Neelakantan, A., Rao, B.S., 1995. Adenoma of nonpigmented epithelium of the ciliary body presenting as anterior uveitis and glaucoma: a case report. Indian J. Ophthalmol., 43(3):137–140.
Council, M.D., Shah, G.K., Lee, H.C., Sharma, S., 2005. Visual outcomes and complications of epiretinal membrane removal secondary to rhegmatogenous retinal detachment. Ophthalmology, 112(7):1218–1221. [doi:10.1016/j.ophtha.2005.01.051]
Cursiefen, C., Schlotzer-Schrehardt, U., Holbach, L.M., Naumann, G.O., 1999. Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris. Arch. Ophthalmol., 117(1):113–116.
Elizalde, J., Ubia, S., Barraquer, R.I., 2006. Adenoma of the nonpigmented ciliary epithelium. Eur. J. Ophthalmol., 16(4):630–633.
Grossniklaus, H.E., Lim, J.I., 1994. Adenoma of the nonpigmented ciliary epithelium. Retina, 14(5):452–456. [doi:10.1097/00006982-199414050-00011]
Harada, C., Harada, T., Mitamura, Y., Quah, H.M., Ohtsuka, K., Kotake, S., Ohno, S., Wada, K., Takeuchi, S., Tanaka, K., 2004. Diverse NF-kappaB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopathy. Mol. Vis., 15(10):31–36.
Harada, C., Mitamura, Y., Harada, T., 2006. The role of cytokines and trophic factors in epiretinal membranes: involvement of signal transduction in glial cells. Prog. Retin. Eye Res., 25(2):149–164. [doi:10.1016/j.preteyeres.2005.09.001]
Johnson, M.W., 2005. Perifoveal vitreous detachment and its macular complications. Trans. Am. Ophthalmol. Soc., 103:537–567.
Mansoor, S., Qureshi, A., 2004. Ciliary body adenoma of nonpigmented epithelium. J. Clin. Pathol., 57(9):997–998. [doi:10.1136/jcp.2004.017871]
McGowan, H.D., Simpson, E.R., Hunter, W.S., Pavlin, C.J., Tanzer, H., 1991. Adenoma of the nonpigmented epithelium of the ciliary body. Can. J. Ophthalmol., 26(6): 328–333.
Nakazawa, T., Abe, T., Sato, Y., Yuda, F., Omura, M., Tamai, M., 2000. Magnetic resonance imaging of a non-pigmented adenoma of the ciliary epitheium. Acta Ophthalmol. Scand., 78(4):470–473. [doi:10.1034/j.1600-0420.2000.078004470.x]
Sebban, H., Courtois, G., 2006. NF-kappaB and inflammation in genetic disease. Biochem. Pharmacol., 72(9): 1153–1160. [doi:10.1016/j.bcp.2006.08.006]
Shields, J.A., Augsburger, J.J., Wallar, P.H., Shah, H.G., 1983. Adenoma of the nonpigmented epithelium of the ciliary body. Ophthalmology, 90(12):1528–1530.
Shields, J.A., Eagle, R.C. Jr, Shields, C.L., de Potter, P., 1996. Acquired neoplasms of the nonpigmented ciliary epithelium (adenoma and adenocarcinoma). Ophthalmology, 103(12):2007–2016.
Suzuki, J., Goto, H., Usui, M., 2005. Adenoma arising from nonpigmented ciliary epithelium concomitant with neovascularization of the optic disk and cystoid macular edema. Am. J. Ophthalmol., 139(1):188–190. [doi:10.1016/j.ajo.2004.06.087]
Szlosarek, P., Charles, K.A., Balkwill, F.R., 2006. Tumour necrosis factor-alpha as a tumour promoter. Eur. J. Cancer, 42(6):745–750. [doi:10.1016/j.ejca.2006.01.012]
Xanthoulea, S., Pasparakis, M., Kousteni, S., Brakebusch, C., Wallach, D., Bauer, J., Lassmann, H., Kollias, G., 2004. Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J. Exp. Med., 200(3):367–376. [doi:10.1084/jem.20040435]
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Project (No. 20010510) supported by the Ministry of Education of Zhejiang Province, China
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Chen, Zq., Fang, Xy. Adenoma of nonpigmented epithelium in ciliary body: literature review and case report. J. Zhejiang Univ. - Sci. B 8, 612–615 (2007). https://doi.org/10.1631/jzus.2007.B0612
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DOI: https://doi.org/10.1631/jzus.2007.B0612