1966 Volume 88 Issue 4 Pages 305-310
Tetrahydrofolate-dependent enzyme activities were investigated upon erythrocyte lysates from two cases with formiminotransferase deficiency syndrome. The activities of both N5, 10-methylene-tetrahydrofolate dehydrogenase and serine-hydroxymethylase were found to be slightly increased. Cyclohydrolase and formate-activating enzyme were found to be normal in their activity.
The results obtained suggested that a metabolic pathway of tetrahydrofolates, including tetrahydrofolate→N5, 10-methylene-tetrahydrofolate→N5, 10-methenyl-tetrahydrofolate→N10-formyltetrahydrofolate, was of an increased activity in erythrocytes in which formiminotransferase was of defective activity.