Effects of Maltose on Insulin Secretion in Perfused Rat Pancreas
1971 Volume 104 Issue 4 Pages 325-330
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1971 Volume 104 Issue 4 Pages 325-330
In this study effect of maltose on the insulin secretion from the rat pancreas was examined according to the perfusion method of Anderson and Grodsky. Solution of Krebs-Ringer bicarbonate buffer containing bovine albumin in four per cent was used as the perfusate. The solution of glucose, maltose, sucrose or lactose was perfused for 30 minutes. No effect of of maltose, sucrose or lactose (400mg/100ml) on the insulin secretion from the perfused rat pancreas was obtained, although glucose (400mg/100ml) stimulated the insulin secretion. These results suggested that maltose was not metabolized enough to release the insulin in the β-cells of the rat pancreas.
