ITEMS

modern scholarly publishers in the finest tradition

Journals

	Search

International Journal of Medicinal Mushrooms

ISSN for PRINT: 1521-9437

Institutional price:	$538.00
Issues per year:	4

Best Paper Award Selection - Editorial Board Site

2008, Volume10

97 pages

DOI: 10.1615/IntJMedMushr.v10.i2

Issue price - $161.00

Antioxidant and Antitumor Activities of Cultured Mycelium of Culinary-Medicinal Paddy Straw Mushroom Volvariella volvacea (Bull.: Fr.) Singer (Agaricomycetideae)

John Mathew
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India

Naraycinci P. Sudheesh
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India

Kuttikkadan A. Rony
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India

Thozhuthumparambil P. Smina
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India

Kainoor K. Jananrdhanan
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India

ABSTRACT

The antioxidant and antitumor properties of cultured mycelium of the medicinal mushroom Volvariella volvacea (paddy straw mushroom) were investigated. An aqueous ethanolic extract of the mycelium showed marked hydroxyl radical scavenging and lipid peroxidation-inhibiting activities. The extract also showed significant DPPH radical scavenging activity and ferric reducing antioxidant power. The antitumor activity of the extract was determined using both the DLA cell line-induced solid tumor and EAC cell line-induced ascites tumor models in mice. The extract showed profound antitumor activity against both ascites and solid tumors. The results thus indicate that paddy straw mushroom mycelium possess significant antioxidant and antitumor properties. This finding suggests the potential therapeutic use of aqueous-ethanolic extracts of V. volvacea mycelium.