In multi-cell wireless systems with insufficient frequency reuse, the downlink transmission suffers from other cell interference (OCI). The cooperative transmission among multiple base stations is an effective way to mitigate OCI and increase the system sum rate. An adaptive scheme for serving one user in each cell was proposed in [1]. In this paper, we generalize the scheme in [2] by serving more than one user in each cell with adaptive OCI cancelation. Based on our derived statistics of a user for different transmission strategies, we propose a low complexity transmission scheme that achieves near-maximal ergodic sum rate. Through numerical examples, we show that the system sum rate can be improved by selecting the appropriate transmission strategy combination adaptively. As a result, our proposed system can explore spatial multiplexing gain without additional power and thus improves the system sum rate significantly.