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KCI 후보

인체피부섬유아세포에서 녹차∙백차∙홍차 열수추출물의 콜라겐 합성능 비교 연구

Comparison in Collagen Synthetic Abilities of Water Extracts of Green Tea, White Tea and Black Tea in Human Dermal Fibroblasts

대한미용학회지
약어 : J Invest Cosmetol
2012 vol.8, no.4, pp.227 - 233
DOI : 10.15810/jic.2012.8.4.002
발행기관 : 대한미용학회
연구분야 : 미용
Copyright © 대한미용학회
312 회 열람

This study was conducted to evaluate the collagen synthetic abilities of water extracts of green tea (GT), white tea (WT)and black tea (BT) in human dermal fibroblasts. In MTT assay, the maximum permissible level for GT, WT and BT was over 200 μg/mL, and that for EGCG was 50 μg/mL. In the experiment of type-I procollagen synthetic ability, TGF-β1(positive control) increased it by 179% (p⁄0.001) at the concentration of 5 ng/mL, compared to the control group. At the concentrations of 12.5, 25, and 50μg/mL, EGCG increased it by 49.3, 80.1 (p⁄0.01), and 141.6% (p⁄0.001), GT increased it by 8.3, 48.1, and 98.5% (p⁄0.01), WT increased it by 10.3, 38.6, 110.4% (p⁄0.05), and BT increased it by 89.5 (p⁄0.01), 96.9 (p⁄0.01), and 114.5% (p⁄0.01), respectively. The order of high to low sequence for the collagen synthetic ability was EGCG¤BT¤WT and GT. It was conformed that GT, WT and BT had high collagen synthetic abilities, and they could be a useful functional natural source for the anti-wrinkle cosmetic materials.

홍차, 콜라겐합성능, 녹차, 인체피부섬유아세포, 백차
Black tea, Collagen synthetic abilities, Green tea, Human dermal fibroblasts, White tea

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