The Understanding persistent Pain Where it ResiDes study of low back pain cohort profile

Authors

  • Luke C. Jenkins Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, New South Wales; School of Health Sciences, Western Sydney University, Penrith, Australia
  • Wei-Ju Chang Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, New South Wales; School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia
  • Valentina Buscemi Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, New South Wales; School of Health Sciences, Western Sydney University, Penrith, Australia
  • Matthew Liston Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, New South Wales; School of Health Sciences, Western Sydney University, Penrith, Australia
  • Michael Nicholas Pain Management Research Institute, University of Sydney at Royal North Shore Hospital, Sydney, Australia
  • Thomas Graven-Nielsen Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
  • Paul W. Hodges The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Australia
  • Valerie C. Wasinger Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Kensington; School of Medical Science, University of New South Wales, Kensington, Australia
  • Laura S. Stone Department of Anesthesiology, Faculty of Medicine, University of Minnesota, Minneapolis, USA
  • Susan G. Dorsey Department of Pain & Translational Symptom Science, University of Maryland Baltimore, Baltimore, USA
  • James H. McAuley Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, New South Wales; University of New South Wales, Neuroscience Research Australia, Sydney, Australia
  • Siobhan M. Schabrun Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, New South Wales, Australia; School of Physical Therapy, University of Western Ontario, London, Ontario, Canada; The Gray Centre for Mobility and Activity, Parkwood Institute, St. Joseph’s Healthcare, London, Ontario, Canada

DOI:

https://doi.org/10.15619/nzjp.v51i3.375

Keywords:

Acute to Chronic, Demographic, Low Back Pain, Neurobiological, Psychological, Social

Abstract

Despite chronic low back pain (LBP) being considered a biopsychosocial condition for diagnosis and management, few studies have investigated neurobiological risk factors thought to underpin the transition from acute to chronic LBP. The aim of this research is to describe the methodology, compare baseline characteristics between acute LBP participants and pain-free controls, and compare LBP participants with or without completed follow-up. One hundred and twenty individuals experiencing acute LBP and 57 pain-free controls were recruited to participate in the Understanding persistent Pain Where it ResiDes (UPWaRD) study. Neurobiological, psychological, and sociodemographic data were collected at baseline, and at 3 and 6 months. Ninety-five participants (79%) provided outcome data at 3-month follow-up and 96 participants (80%) at 6 months. Compared to controls, LBP participants in the UPWaRD cohort were older, had a higher BMI, a higher prevalence of comorbidities, and higher medication usage. Higher depression, anxiety and stress, lower pain self-efficacy, and higher pain catastrophising during acute LBP were correlated with higher 6-month pain and disability. This cohort provides novel and significant opportunities to increase understanding of neurobiological risk factors of LBP. Future findings endeavour to provide new targets for treatment and prevention of chronic LBP. Additional priorities include exploring epigenetic and proteomic biomarkers of poor LBP outcome.

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Published

28-11-2023

How to Cite

Jenkins, L. C., Chang, W.-J., Buscemi, V., Liston, M., Nicholas, M., Graven-Nielsen, T., Hodges, P. W., Wasinger, V. C., Stone, L. S., Dorsey, S. G., McAuley, J. H., & Schabrun, S. M. (2023). The Understanding persistent Pain Where it ResiDes study of low back pain cohort profile. New Zealand Journal of Physiotherapy, 51(3), 199–216. https://doi.org/10.15619/nzjp.v51i3.375

Issue

Vol. 51 No. 3 (2023): New Zealand Journal of Physiotherapy

Section

Research Report