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Micromolding in Capillaries for the Generation of Molecularly Imprinted Polymer Filaments and Microstructures

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Abstract

The technique of micromolding in capillary has been employed to prepare molecularly imprinted polymer microfilaments, and to pattern MIP structures on silicon wafers. The approach relies on crosslinked poly(dimethylsiloxane) that contains relief structures as a mold to define the shape and size of the imprinted polymers. This article describes the processes leading to the fabrication of free-standing MIP micromonoliths and covalently immobilized MIP microstructures on silicon wafers. The limitations of the technique are also discussed.

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References

  1. H. Zhu, M. Bilgin, R. Bangham, D. Hall, A. Casamayor, P. Bertone, N. Lan, R. Jansen, S. Bidlingmaier, T. Houfek, T. Mitchell, P. Miller, R. A. Dean, M. Gerstein, and M. Snyder, Science 293, 2101–2105 (2001).

    Article  CAS  Google Scholar 

  2. T. Chen, S. C. Barton, G. Binyamin, Z. Gao, Y. Zhang, H-H Kim, and A. Heller, J. Am. Chem. Soc. 123, 8630–8631 (2001).

    Article  CAS  Google Scholar 

  3. C. Hagleitner, A. Hierlemann, D. Lange, A. Kummer, N. Kerness, O. Brand, and H. Baltes, Nature 414, 293–296 (2001).

    Article  CAS  Google Scholar 

  4. M. Aiello and R. McLaren, Anal. Chem. 73, 1387–1392 (2001).

    Article  CAS  Google Scholar 

  5. T. A. T. Andrew Taton, C. A. Mirkin, and R. L. Letsinger, Science 289, 1757–1760 (2000).

    Article  Google Scholar 

  6. F. Favier, E. C. Walter, M. P. Zach, T. Benter, and R. M. Penner, Science 293, 2227–2231 (2001).

    Article  CAS  Google Scholar 

  7. J. Wang and X. Zhang, Anal. Chem. 73, 844–847 (2001).

    Article  CAS  Google Scholar 

  8. Man-Made Mimics of Antibodies and their Application in Analytical Chemistry, ed. B. Sellegren (Elsevier Science, New York, 2000).

    Google Scholar 

  9. G. Wulff, Chem. Rev. 102, 1–28 (2002).

    Article  CAS  Google Scholar 

  10. K. Haupt and K. Mosbach, Chem. Rev. 100, 2495–2504 (2000).

    Article  CAS  Google Scholar 

  11. Y. Xia and G. M. Whitesides, Angew. Chem. Int. Ed. 37, 550–575 (1998).

    Article  CAS  Google Scholar 

  12. X.-M. Zhao, Y. Xia, and G. M. Whitesides, J. Mater. Chem. 7, 106901074 (1997).

    Google Scholar 

  13. E. Kim, Y. Xia, and G. M. Whitesides, J. Am. Chem. Soc. 118, 5722–5731 (1996).

    Article  CAS  Google Scholar 

  14. E. Kim, Y. Xia, and G. M. Whitesides, Nature 376, 581–584 (1995).

    Article  CAS  Google Scholar 

  15. J. A. Bride, S. Baskaran, N. Taylor, J. W. Halloran, W. H. Juan, S. W. Pang, and M. O’Donnell, Appl. Phys. Lett. 63, 3379–3381 (1993).

    Article  CAS  Google Scholar 

  16. A. Kumar and G. M. Whitesides, Appl Phys. Lett. 63, 2002–2004 (1993).

    Article  CAS  Google Scholar 

  17. a) M. Yan and A. Kapua, Anal. Chim. Acta 435, 163–167. (2001). b) M. Yan and A. Kapua, Polym. Preprint 41, 264-265 (2000).

    Article  CAS  Google Scholar 

  18. J. Brazier and M. Yan, Mater. Res. Soc. Symp. Proc., submitted (2002).

    Google Scholar 

  19. Z. Bao, J. A. Rogers, and H. E. Katz, J. Mater. Chem. 9, 1895–1904 (1999).

    Article  CAS  Google Scholar 

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Yan, M. Micromolding in Capillaries for the Generation of Molecularly Imprinted Polymer Filaments and Microstructures. MRS Online Proceedings Library 723, 22 (2002). https://doi.org/10.1557/PROC-723-M2.2

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  • DOI: https://doi.org/10.1557/PROC-723-M2.2

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