Effects of Converting Enzyme Inhibitor (SQ 20881) on Changes in Blood Pressure and Plasma Aldosterone Induced by Angiotensin I or Acute Hemorrhage in Rabbits

Ikuo SAITO; Toyohisa EGUCHI; Ryuichi NAKAMURA; Jiro MISUMI; Kazuoki KONDO; Takao SARUTA

doi:10.1536/ihj.21.95

Ikuo SAITO, Toyohisa EGUCHI, Ryuichi NAKAMURA, Jiro MISUMI, Kazuoki KONDO, Takao SARUTA

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Keywords: Plasma renin activity

JOURNAL FREE ACCESS

1980 Volume 21 Issue 1 Pages 95-101

DOI https://doi.org/10.1536/ihj.21.95

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Abstract

The effects of angiotensin converting enzyme inhibitor (CEI) upon blood pressure and plasma aldosterone (PA) were studied in rabbits with a simultaneous infusion of angiotensin I (ANG I) or with hemorrhagic hypotension.
Pretreatment with CEI (SQ 20881), 1.0mg/Kg, inhibited the effects of infused ANG I, 30ng/Kg/min, upon PA and blood pressure at 30min of the infusion, but the inhibition on PA was not significant at 60min of the infusion. The same dose of CEI was ineffective in blocking the effect of 100ng/Kg/min of ANG I on PA and blood pressure even at 30min of the infusion.
In rabbits with hemorrhagic hypotension, injection of CEI resulted in the decrement in blood pressure, whereas no decrement in blood pressure was observed in normal control rabbits.

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