Antihypertensive Effect of 4 (-2'-Nitrophenyl)-2, 6-Dimethyl-1, 4-Dihydropyridine-3, 5-Dicarbonic Acid Dimethylester (Nifedipine, Bay-a 1040), a New Coronary Dilator

Mototaka MURAKAMI; Eiji MURAKAMI; Noboru TAKEKOSHI; Masayuki TSUCHIYA; Takeo KIN; Tamehisa ONOE; Nobuo TAKEUCHI; Toshiro FUNATSU; Shigeki HARA; Shozo ISHISE; Junichiro MIFUNE; Masahiro MAEDA

doi:10.1536/ihj.13.128

Mototaka MURAKAMI, Eiji MURAKAMI, Noboru TAKEKOSHI, Masayuki TSUCHIYA, Takeo KIN, Tamehisa ONOE, Nobuo TAKEUCHI, Toshiro FUNATSU, Shigeki HARA, Shozo ISHISE, Junichiro MIFUNE, Masahiro MAEDA

Author information

Mototaka MURAKAMI
Second Department of Medicine, Kanazawa University
Eiji MURAKAMI
Second Department of Medicine, Kanazawa University
Noboru TAKEKOSHI
Second Department of Medicine, Kanazawa University
Masayuki TSUCHIYA
Second Department of Medicine, Kanazawa University
Takeo KIN
Second Department of Medicine, Kanazawa University
Tamehisa ONOE
Second Department of Medicine, Kanazawa University
Nobuo TAKEUCHI
Second Department of Medicine, Kanazawa University
Toshiro FUNATSU
Second Department of Medicine, Kanazawa University
Shigeki HARA
Second Department of Medicine, Kanazawa University
Shozo ISHISE
Second Department of Medicine, Kanazawa University
Junichiro MIFUNE
Second Department of Medicine, Kanazawa University
Masahiro MAEDA
Second Department of Medicine, Kanazawa University

Keywords: Bay-a1040, Systolic pressure, Heart rate, Cardiac output, Total peripheral resistance, Left ventricular work

JOURNAL FREE ACCESS

1972 Volume 13 Issue 2 Pages 128-135

DOI https://doi.org/10.1536/ihj.13.128

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Abstract

Oral administration of 10mg. of Bay-a 1040, a new coronary dilator, produced a marked reduction of arterial pressure which was associated with a consistent decrease in peripheral vascular resistance and an increase in cardiac output and stroke volume. Changes in heart rate and left ventricular work were variable. In 20 hypertensive patients treated with the drug in doses of 10mg. per day, a modest antihypertensive effect was achieved. Side effects including dryness of the mouth and burning sensation in face and legs, were observed in few patients.

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