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Originally published as Genetics Published Articles Ahead of Print on May 4, 2007.
Genetics, Vol. 176, 1339-1342, June 2007, Copyright © 2007
doi:10.1534/genetics.107.072983
Manipulating Mitotic Recombination in the Zebrafish Embryo Through RecQ Helicases
Jing Xie*,
Seneca L. Bessling*,
Timothy K. Cooper*,
,
Harry C. Dietz*,
Andrew S. McCallion*, and
Shannon Fisher*,
,1
* McKusick–Nathans Institute of Genetic Medicine, Department of Molecular and Comparative Pathobiology and Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
1 Corresponding author: The McKusick–Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 733 N. Broadway, BRB 455, Baltimore, MD 21205.
E-mail: sfisher{at}jhmi.edu
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.