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Human T-Cell Leukemia Virus Type 1 Tax and Cellular Transformation

  • Progress in Hematology
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Abstract

Infection of T-cells by human T-cell leukemia virus type 1 (HTLV-1) causes a lymphoproliferative malignancy known as adult T-cell leukemia (ATL). ATL is characterized by abnormal lymphocytes, calledflower cells, which have cleaved and convoluted nuclei. Tax, encoded by the HTLV-1 pX region, is a critical nonstructural protein that plays a central role in leuke-mogenesis; however, the mechanisms of HTLV-1 oncogenesis have not been clarified fully. In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis.

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Authors and Affiliations

  1. Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 306, 9000, Rockville Pike, 20892-0460, Bethesda, Maryland, USA

    Jean-Marie Peloponese, Takao Kinjo & Kuan-Teh Jeang

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  1. Jean-Marie Peloponese
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  2. Takao Kinjo
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  3. Kuan-Teh Jeang
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Correspondence to Kuan-Teh Jeang.

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Peloponese, JM., Kinjo, T. & Jeang, KT. Human T-Cell Leukemia Virus Type 1 Tax and Cellular Transformation. Int J Hematol 86, 101–106 (2007). https://doi.org/10.1532/IJH97.07087

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  • DOI: https://doi.org/10.1532/IJH97.07087

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