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Primary Gastric Hodgkin’s Lymphoma Expressing a B-Cell Profile Including Oct-2 and Bob-1 Proteins

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Abstract

Classic Hodgkin’s lymphoma (cHL) most often involves lymph nodes, and gastric involvement is rare. Hodgkin’s and Reed-Sternberg (H-RS) cells in cHL are known to often lack expression of several B-lineage markers, such as CD20, CD79a, Oct-2, and Bob-1. We present an extremely rare case of mixed-cellularity cHL in the stomach in which expression of these B-cells was detected immunohistochemically. The patient was an 83-year-old Japanese woman who developed a sensation of abdominal fullness and appetite loss. Endoscopic and abdominal computed tomography examinations revealed a gastric ulcer lesion and swelling of para-aortic lymph nodes, respectively. A subtotal gastrectomy was performed, and the histopathologic diagnosis was established as a typical cHL compatible with stomach origin. The patient underwent postoperative chemotherapy of 3 cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and has since been in complete remission. Immunohistochemically, the H-RS cells in the cHL were positive not only for CD30 but also for CD20, CD79a, Oct-2, and Bob-1, whereas they were negative for CD3, CD15, CD45, EMA, and ALK1. Our patient may have had an intermediate cHL disease overlapping that of non-Hodgkin’s peripheral B-cell lymphoma, possibly reflecting derivation from germinal-center B-cells.

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Authors and Affiliations

  1. Department of Internal Medicine, Aiiku Hospital, Kita 3 Nishi 16-1, Chuo-ku, 060-0003, Sapporo, Japan

    Makoto Saito, Akio Mori, Nobuyasu Toyoshima, Tatsuro Irie & Masanobu Morioka

  2. Molecular and Cellular Pathology, Hokkaido University School of Medicine, Sapporo, Japan

    Makoto Saito & Shinya Tanaka

Authors
  1. Makoto Saito
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  2. Shinya Tanaka
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  3. Akio Mori
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  4. Nobuyasu Toyoshima
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  5. Tatsuro Irie
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  6. Masanobu Morioka
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Correspondence to Makoto Saito.

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Saito, M., Tanaka, S., Mori, A. et al. Primary Gastric Hodgkin’s Lymphoma Expressing a B-Cell Profile Including Oct-2 and Bob-1 Proteins. Int J Hematol 85, 421–425 (2007). https://doi.org/10.1532/IJH97.06094

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  • DOI: https://doi.org/10.1532/IJH97.06094

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