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Adoptive Immunotherapy for Hodgkin’s Lymphoma

  • Progress in Hematology
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Abstract

Adoptive transfer of tumor-specific T-cells is an attractive strategy for the treatment of patients with refractory or relapsed Hodgkin’s lymphoma. However, Hodgkin’s lymphomas possess a range of tumor-evasion mechanisms, which must be overcome before the full potential of immunotherapies can be achieved. In this article, we discuss the promise of Epstein-Barr virus-specific cytotoxic T-lymphocytes, the roles of cytokines, and other strategies for overcoming the immune-evasion mechanisms in Hodgkin’s lymphoma.

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Authors and Affiliations

  1. Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children’s Hospital, 6621 Fannin St, MC3-3320, 77030, Houston, TX, USA

    Alana A. Kennedy-Nasser, Catherine M. Bollard & Cliona M. Rooney

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  1. Alana A. Kennedy-Nasser
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  2. Catherine M. Bollard
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  3. Cliona M. Rooney
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Correspondence to Catherine M. Bollard.

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Kennedy-Nasser, A.A., Bollard, C.M. & Rooney, C.M. Adoptive Immunotherapy for Hodgkin’s Lymphoma. Int J Hematol 83, 385–390 (2006). https://doi.org/10.1532/IJH97.06107

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  • DOI: https://doi.org/10.1532/IJH97.06107

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