지모 추출물의 피부 미백 및 항산화 효과 연구

최찬헌; 정현우

doi:10.15188/kjopp.2020.04.34.2.67

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저널정보

한의병리학회
동의생리병리학회지 학술저널
동의생리병리학회지 제34권 제2호
2020.04 67 - 74 (8page)
DOI : 10.15188/kjopp.2020.04.34.2.67

저자정보

최찬헌 (동신대학교)
정현우 (동신대학교)

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초록·키워드

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The objective of this study is to investigate the skin whitening and antioxidant effects of the Anemarrhenae Rhizoma extract (ARE). Following the previously studied method, we examined the inhibitory effects of melanin synthesis and tyrosinase activity by using B16F10 cells. First, we measured the Diphenylpicrylhydrazyl (DPPH) assay, nitrite scavenging activity, and superoxide dismutase-like activity to verifying antioxidant efficacy according to skin whitening. In addition, we confirmed the skin whitening efficacy of ARE by measuring gene expression associated with a skin whitening by the Reverse transcription polymerase chain reaction (RT-PCR) method in B16F10 cells. In this study, we confirmed that ARE has skin whitening and antioxidant effects at high concentrations. In particular, ARE at a concentration of 500 ㎍/ml inhibited the expression of Tyrosinase, TRP-2 (tyrosinase-related protein), and MITF (microphthalmia transcription factor) genes better than Arbutin. In conclusion, our results confirmed that ARE has the potential for development as a skin whitening efficacy substance.

#Anemarrhenae Rhizoma #Melanin #Tyrosinase #Skin whitening #Antioxidant