Logo-bi
Bioimpacts. 2017;7(3): 193-198.
doi: 10.15171/bi.2017.22
PMID: 29159146
PMCID: PMC5684510
Scopus ID: 85032022290
  Abstract View: 3356
  PDF Download: 1913
  Full Text View: 1450

Original Research

Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signalling pathways

Abbas Asoudeh-Fard 1,2, Abolfazl Barzegari 1, Alireza Dehnad 2,3, Sepideh Bastani 1, Asal Golchin 1, Yadollah Omidi 1.4* ORCID logo

1 Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran
3 Biotechnology Department, East Azerbaijan Research and Education Center for Agricultural and Natural Resources, AREEO, Tabriz Iran
4 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: yadollah.omidi@gmail.com

Abstract

Introduction: The oral tumor is the sixth most prevalent type of cancer worldwide and the second leading cause of cancer-related mortality. Although chemotherapy and immunotherapy are the main strategies for the treatment of oral cancer, an emergence of inevitable resistance to these treatment modalities is the major drawback that causes recurrence of the disease. Nowadays, probiotics have been suggested as adjunctive and complementary treatment modalities for improving the impacts of chemotherapy and immunotherapy agents. Probiotics, the friendly microflora in our bodies, contribute to the production of useful metabolites with positive effects on the immune system against various diseases such as cancer. 

Methods: Lactobacillus plantarum is one of the most important bacteria, which commensally live in the human oral system. In the current study, the impacts of L. plantarum on maintaining oral system health were investigated, and the molecular mechanisms of inhibition of oral cancer KB cells mediated by L. plantarum were evaluated using real-time polymerase chain reaction (PCR) and FACS flow cytometry analyses. 

Results: Our findings showed that L. plantarum is effective in the signal transduction of the oral cancer cells through upregulation and downregulation of PTEN and MAPK pathways, respectively.

Conclusion: Based on the biological effects of oral candidate probiotics candidate bacterium L. plantarum on functional expression of PTEN and MAPK pathways, this microorganism seems to play a key role in controlling undesired cancer development in the oral system. Taken all, L. plantarum is proposed as a potential candidate for probiotics cancer therapy.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 3357

Your browser does not support the canvas element.


PDF Download: 1913

Your browser does not support the canvas element.


Full Text View: 1450

Your browser does not support the canvas element.

Submitted: 06 Mar 2017
Revision: 01 May 2017
Accepted: 25 May 2017
ePublished: 07 Jun 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)