Abstract
Flavonoids amongst the class of secondary metabolites possess numerous health benefits, are known for its use in pharmaceutical industry. Quercetin, a flavonoid has more prominent medical advantages however its utilization is constrained because of various instability and insolubility issues and therefore, taken into consideration for studying its physico-chemical properties. In view of that, the thermodynamic and thermoacoustic properties of quercetin were examined in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB) at different hydroethanolic concentrations and temperatures. The conductivity studies were used to calculate change in enthalpy (∆H o m ), change in entropy (∆S o m ) and change in Gibbs free Energy (∆G o m ) of micellization. The interactions between quercetin and CTAB were found to be endothermic, entropically controlled and spontaneous. Further, ultrasonic sound velocity and density studies were carried out and utilized for the calculation of thermoacoustic parameters i.e. apparent molar volume and apparent molar compressibility. Thermoacoustic properties revealed that at higher surfactant concentration, hydrophobic interactions are dominant. The results suggested that the flavonoid-surfactant interactions in hydroethanolic solutions is more favourable as compared with aqueous solution. Overall, the data is favourable for the framework to be used for detailing advancement, drug development, drug industry, pharmaceutical industry, medical administration and formulation development studies.
Funding source: Science and Engineering Research Board, India 10.13039/501100001843
Award Identifier / Grant number: EMR/2016/004791
Acknowledgements
The authors V.Abbot and P.Sharma are thankful to Science and Engineering Research Board (DST-SERB), Government of India, for providing financial support in form of a major research project (Project Reference No. EMR/2016/004791).
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Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: The study was funded by the Science and Engineering Research Board, India (Project Award Number: EMR/2016/004791).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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