Abstract
Three sesquiterpene lactones (1–3) were isolated from the aerial part of Tithonia diversifolia (Hemsl.) A. Gray grown in the Hoa Binh province in Viet Nam. The structures of these three sesquiterpene lactones were identified as tagitinin A (1), 1β-hydroxytirotundin 3-O-methyl ether (2), and tagitinin C (3) by analyzing spectroscopic data. For the first time, compound 2 was isolated from T. diversifolia growing in Viet Nam. Furthermore, contrary to existing literature, we determined that compound 1 was the major isolate. Compounds 1 and 3 significantly decreased numbers of acute myeloid leukemia OCI-AML3 cells by promoting apoptosis and causing cell cycle arrest at G0/G1 phase at concentrations as low as 2.5 μg/mL (compound 1) and 0.25 μg/mL (compound 3). Additionally, all three compounds showed cytotoxic activity against five human cancer cell lines (A549, T24, Huh-7, 8505, and SNU-1), with IC50 values ranging from 1.32 ± 0.14 to 46.34 ± 2.74 μM. Overall, our findings suggest that compounds 1 and 3 may be potential anti-cancer therapeutics and thus warrant further study.
Funding source: Vietnam Academy of Science and Technology (VAST)
Award Identifier / Grant number: NCVCC06.08/22-23
Funding source: PhD Scholarship Programme of Vingroup Innovation Foundation
Award Identifier / Grant number: VINIF.2021.TS.071
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This research was financially supported by the Vietnam Academy of Science and Technology (under project NCVCC06.08/22-23). Nguyen Thi Thuy Linh was supported by the PhD Scholarship Programme of Vingroup Innovation Foundation (Code VINIF.2021.TS.071).
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Conflict of interest statement: The authors report no conflicts of interest.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2021-0154).
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