Metal-assisted Oxidative Cyclization of Arylamidrazones II [1]. Novel Synthesis of 1,4-Diaryl[1,2,4]triazino[6,5-h]quinolines

Monther A. Khanfar; Bassam A. Abu Thaher; Jalal A. Zahra; Raed A. Al-Qawasmeh; Mustafa M. El-Abadelah; Wolfgang Voelter

doi:10.1515/znb-2008-0915

Open Access Published by De Gruyter June 2, 2014

Metal-assisted Oxidative Cyclization of Arylamidrazones II [1]. Novel Synthesis of 1,4-Diaryl[1,2,4]triazino[6,5-h]quinolines

Monther A. Khanfar , Bassam A. Abu Thaher , Jalal A. Zahra , Raed A. Al-Qawasmeh , Mustafa M. El-Abadelah and Wolfgang Voelter

From the journal Zeitschrift für Naturforschung B

https://doi.org/10.1515/znb-2008-0915

New model 1,2,4-triazino[6,5-h]quinolines 8a - c are prepared by oxidative cyclization of the respective N-(quinolin-8-yl)amidrazone precursors 7a - c using copper(II) chloride. Interestingly, the cyclized products 8a - c were found to be arylated at N1 position. Analytical and spectral (MS, NMR) data of the title products are in compliance with the allocated structures.

Keywords: α-Acetyl-N-arylhydrazonoyl Chlorides; 8-Aminoquinoline; Arylamidrazones; CuCl2-catalyzed Cyclization; as-Triazino[6,5-h]quinolines

Received: 2008-5-29

Published Online: 2014-6-2

Published in Print: 2008-9-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Metal-assisted Oxidative Cyclization of Arylamidrazones II [1]. Novel Synthesis of 1,4-Diaryl[1,2,4]triazino[6,5-h]quinolines

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