Abstract
With the rapid development of nanotechnology during the past several years, attention has been focused on metallic nanomaterials, due to their specific physical and chemical characteristics. Zinc oxide nanoparticles (ZnO NPs) have numerous potential applications in industry, as a part of various consumer products, but also in medical research. Anticancer properties of ZnO NPs have been suggested in cell cultures, however, the precise mechanism responsible for their activity in these conditions remains elusive. Cytotoxicity and genotoxicity of ZnO NPs are also unclear. Apart from cancer research, ZnO NPs are today widely researched in almost all areas of fundamental medicine. In this short review, we discuss recently published articles on ZnO NPs applications in cellular physiology, pathology, neurosciences and oncology.
References
[1] K.H. Bae, H.J. Chung, and T.G. Park, Mol Cells, 31 (2011) 295-302.10.1007/s10059-011-0051-5Search in Google Scholar PubMed PubMed Central
[2] J.A. Barreto, W. O’Malley, M. Kubeil, B. Graham, H. Stephan, and L. Spiccia, Adv Mater, 23 (2011) H18-40.10.1002/adma.201100140Search in Google Scholar PubMed
[3] A. Bhardwaj, A. Bhardwaj, A. Misuriya, S.Maroli, S.Manjula, and A.K. Singh, J Int Oral Health, 6 (2014) 121-126.Search in Google Scholar
[4] Y. Huang, S. He,W. Cao, K. Cai, and X.J. Liang, Nanoscale, 4 (2012) 6135-6149.10.1039/c2nr31715jSearch in Google Scholar PubMed
[5] S. Marin, G.M. Vlasceanu, R.E. Tiplea, I.R. Bucur, M. Lemnaru, M.M. Marin, et al., Curr Top Med Chem, 15 (2015) 1596-1604.10.2174/1568026615666150414142209Search in Google Scholar PubMed
[6] J.R. Morones, J.L. Elechiguerra, A. Camacho, K. Holt, J.B. Kouri, J.T. Ramirez, et al., Nanotechnology, 16 (2005) 2346-2353.10.1088/0957-4484/16/10/059Search in Google Scholar PubMed
[7] S. Chernousova and M. Epple, Angew Chem Int Ed Engl, 52 (2013) 1636-1653.10.1002/anie.201205923Search in Google Scholar PubMed
[8] A.R. Ferhan, L. Guo, X. Zhou, P. Chen, S. Hong, and D.H. Kim, Anal Chem, 85 (2013) 4094-4099.10.1021/ac4001817Search in Google Scholar PubMed
[9] K. Hola, Z. Markova, G. Zoppellaro, J. Tucek, and R. Zboril, Biotechnol Adv, 33 (2015) 1162-1176.10.1016/j.biotechadv.2015.02.003Search in Google Scholar PubMed
[10] B. Song, Y. Zhang, J. Liu, X. Feng, T. Zhou, and L. Shao, Nanoscale Res Lett, 11 (2016) 291.10.1186/s11671-016-1508-4Search in Google Scholar PubMed PubMed Central
[11] D. Nikolovski, M. Jeremic, J. Paunovic, D. Vucevic, T. Radosavljevic, S. Radojevic-Skodric, et al., Rev Adv Mater Sci, 53 (2018) 74-78.10.1515/rams-2018-0005Search in Google Scholar
[12] J. Paunovic, D. Vucevic, T. Radosavljevic, S. Pantic, D. Nikolovski, and I. Pantic, Rev Adv Mater Sci, 49 (2017) 123-128.Search in Google Scholar
[13] D. Nikolovski, S. Dugalic, and I. Pantic, J Microsc, 268 (2017) 45-52.10.1111/jmi.12585Search in Google Scholar
[14] I. Pantic, Sci Prog, 94 (2011) 97-107.10.3184/003685011X12979697342151Search in Google Scholar PubMed
[15] I. Pantic, Rev Adv Mater Sci, 37 (2014) 15-19.Search in Google Scholar
[16] I. Pantic, Rev Adv Mater Sci, 26 (2010) 67-73.Search in Google Scholar
[17] P.K. Mishra, H. Mishra, A. Ekielski, S. Talegaonkar, and B. Vaidya, Drug Discov Today, 22 (2017) 1825-1834.10.1016/j.drudis.2017.08.006Search in Google Scholar PubMed
[18] C.H. Li, P.L. Liao, M.K. Shyu, C.W. Liu, C.C. Kao, S.H. Huang, et al., Toxicol Sci, 126 (2012) 162-172.10.1093/toxsci/kfr331Search in Google Scholar
[19] L. Wang, C. Chen, L. Guo, Q. Li, H. Ding, H. Bi, et al., Artif Cells Nanomed Biotechnol, 28 (2018) 1-12.Search in Google Scholar
[20] R. Roy, S.K. Singh, M. Das, A. Tripathi, and P.D. Dwivedi, Immunology, 142 (2014) 453-464.10.1111/imm.12276Search in Google Scholar PubMed PubMed Central
[21] R. Roy, D. Kumar, A. Sharma, P. Gupta, B.P. Chaudhari, A. Tripathi, et al., Toxicol Lett, 230 (2014) 421-433.10.1016/j.toxlet.2014.08.008Search in Google Scholar PubMed
[22] D.P. Bai, X.F. Zhang, G.L. Zhang, Y.F. Huang, and S. Gurunathan, Int J Nanomedicine, 12 (2017) 6521-6535.10.2147/IJN.S140071Search in Google Scholar PubMed PubMed Central
[23] J.W. Rasmussen, E. Martinez, P. Louka and D.G. Wingett, Expert Opin Drug Deliv, 7 (2010) 1063-1077.10.1517/17425247.2010.502560Search in Google Scholar PubMed PubMed Central
[24] S. Ostrovsky, G. Kazimirsky, A. Gedanken and C. Brodie, Nano Res, 2 (2009) 882-890.10.1007/s12274-009-9089-5Search in Google Scholar
[25] M.J. Akhtar, M. Ahamed, S. Kumar, M.M. Khan, J. Ahmad, and S.A. Alrokayan, Int J Nanomedicine, 7 (2012) 845-857.Search in Google Scholar
[26] A. Thurber, D.G. Wingett, J.W. Rasmussen, J. Layne, L. Johnson, D.A. Tenne, et al., Nanotoxicology, 6 (2012) 440-452.10.3109/17435390.2011.587031Search in Google Scholar PubMed
[27] G. Bisht and S. Rayamajhi, Nanobiomedicine, 3 (2016) 9.10.5772/63437Search in Google Scholar PubMed PubMed Central
[28] C. Wang, X. Hu, Y. Gao, and Y. Ji, Biomed Res Int, 2015 (2015) 423287.10.1155/2015/423287Search in Google Scholar PubMed PubMed Central
[29] A.K. Sharma, V. Singh, R. Gera, M.P. Purohit, and D. Ghosh, Mol Neurobiol, 54 (2017) 6273-6286.10.1007/s12035-016-0133-7Search in Google Scholar PubMed
[30] D. Guo, H. Bi, D. Wang, and Q. Wu, Int J Biochem Cell Biol, 45 (2013) 1849-1859.10.1016/j.biocel.2013.06.002Search in Google Scholar PubMed
[31] D. Guo, H. Bi, Q. Wu, D. Wang, and Y. Cui, J Nanosci Nanotechnol, 13 (2013) 3769-3777.10.1166/jnn.2013.7169Search in Google Scholar PubMed
[32] X.Q. Liu, H.F. Zhang, W.D. Zhang, P.F. Zhang, Y.N. Hao, R. Song, et al., Toxicol Lett, 256 (2016) 19-32.10.1016/j.toxlet.2016.05.007Search in Google Scholar PubMed
[33] F. Xiaoli, W. Junrong, L. Xuan, Z. Yanli, W. Limin, L. Jia, et al., Nanomedicine (Lond), 12 (2017) 777-795.10.2217/nnm-2016-0397Search in Google Scholar PubMed
[34] S. Amara, I.B. Slama, K. Omri, J. El Ghoul, L. El Mir, K.B. Rhouma, et al., Toxicol Ind Health, 31 (2015) 1202-1209.10.1177/0748233713491802Search in Google Scholar PubMed
[35] S. Amara, I. Ben-Slama, I. Mrad, N. Rihane, M. Jeljeli, L. El-Mir, et al., Nanotoxicology, 8 Suppl 1 (2014) 208-215.10.3109/17435390.2013.879342Search in Google Scholar PubMed
[36] C. Chen, W. Bu, H. Ding, Q. Li, D. Wang, H. Bi and D. Guo, Cell Prolif 50 (2017).10.1111/cpr.12339Search in Google Scholar PubMed PubMed Central
[37] L. Tian, B. Lin, L. Wu, K. Li, H. Liu, J. Yan, X. Liu, and Z. Xi, Sci Rep 5 (2015) 16117.10.1038/srep16117Search in Google Scholar PubMed PubMed Central
[38] S. Sruthi and P.V. Mohanan, Colloids Surf B Biointerfaces, 133 (2015) 1-11.10.1016/j.colsurfb.2015.05.041Search in Google Scholar PubMed
[39] M.G. Amer and R.A. Karam, Anat Rec (Hoboken) (2018).Search in Google Scholar
[40] M. Afifi and A.M. Abdelazim, Asian Pacific Journal of Tropical Biomedicine, 5 (2015) 874-877.10.1016/j.apjtb.2015.06.010Search in Google Scholar
© 2019 Senka Pantic et al., published by De Gruyter Open
This work is licensed under the Creative Commons Attribution 4.0 Public License.
