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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) July 20, 2019

Chelators and metal complex stability for radiopharmaceutical applications

  • Nkemakonam C. Okoye , Jakob E. Baumeister , Firouzeh Najafi Khosroshahi , Heather M. Hennkens EMAIL logo and Silvia S. Jurisson EMAIL logo
From the journal Radiochimica Acta

Abstract

Diagnostic and therapeutic nuclear medicine relies heavily on radiometal nuclides. The most widely used and well-known radionuclide is technetium-99m (99mTc), which has dominated diagnostic nuclear medicine since the advent of the 99Mo/99mTc generator in the 1960s. Since that time, many more radiometals have been developed and incorporated into potential radiopharmaceuticals. One critical aspect of radiometal-containing radiopharmaceuticals is their stability under in vivo conditions. The chelator that is coordinated to the radiometal is a key factor in determining radiometal complex stability. The chelators that have shown the most promise and are under investigation in the development of diagnostic and therapeutic radiopharmaceuticals over the last 5 years are discussed in this review.

Acknowledgments

The authors acknowledge the University of Missouri Fellowship Program (J. E. Baumeister) in Radiochemistry supported by a grant to The Curators of the University of Missouri under award #NRC-HQ-15-G-0036, from the Office of the Chief Human Capital Officer of the Nuclear Regulatory Commission. Any statements, findings, conclusions, and recommendations are those of the author(s) and do not necessarily reflect the view of the Outreach and Recruitment Branch of the US Nuclear Regulatory Commission. The authors gratefully acknowledge support from the US Department of Energy, Office of Science, Isotope Research Program under grants DE-SC0018662 and DE-SC0018013 (F. Najafi Khosroshahi).

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Received: 2018-12-14
Accepted: 2019-06-25
Published Online: 2019-07-20
Published in Print: 2019-09-25

© 2019 Walter de Gruyter GmbH, Berlin/Boston

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