Abstract
We aimed to collect data on all paediatric patients who were diagnosed with type 1 diabetes mellitus (T1DM) between the years 2000 and 2019 in Serbia and estimate for the first time its prevalence. Also, the trends of diabetes ketoacidosis (DKA) occurrence at the time of diagnosis are monitored. We collected and retrospectively analysed the data of patients <19 years with newly diagnosed T1DM. T1DM was diagnosed in 3134 patients (53.2% male). Total number of youth <19 years with T1DM was 1735 with prevalence of 135.25/100000 at the end of study period. T1DM was diagnosed most frequently between the ages of 5 and 11 years (42.1%). At the time of diagnosis, 35.7% presented in DKA. The incidence and severity of DKA were more significant at the youngest age (p<0.001). There were significant annual percentage increase (2.2%) in the number of new cases of DKA (p=0.007). Conclusion: This first report of nationwide prevalence of T1DM in youth shows that Serbia is among countries with high prevalence of T1DM in youth. System changes are needed in order to provide better quality of health care to these patients.
Research funding: No funding was received for the present study.
Author contributions: Sandra Stankovic, Rade Vukovic designed the research study, gathered the data from respective centres, analysed data from all centers, conducted statistical analyses and wrote the first version of the manuscript. IvanaVorgucin, Sandra Stankovic, and Vera Zdravkovic, Maja D Jesic, Nevena Folic gathered the data from respective centers, contributed to study design and revised the manuscript. Tatjana Milenkovic, Silvija Sajic, Dragan Katanic, Sasa Zivic, Ljiljana Saranac and Slavica Markovic contributed to study design and revised the manuscript. Vesna Cvetkovic, Katarina Mitrovic, SlađanaTodorovic, Slavica Dautovic, Tatjana Tucakovic, Snezana Lesovic, Mirjana Ljubojevic, Tatjana Ilic, MirjanaVrebalov, Marina Mikic, Bratimirka Jelenkovic, Rada Petrovic, Snezana Saric, Danijela Simić, Milanko Cukanovic gathered the data from respective centres. Aleksandra Ignjatovic, Miodrag Stankovic conducted statistical analyses. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Conflict of interest: The authors declare that they have no conflict of interest.
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