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ABSTRACT
Type 2 diabetes mellitus (DM) has been considered rare in the pediatric population. However, over the last decade, there has been a disturbing upswing in the rate of diagnosis of type 2 DM in the pediatric age group, mirroring the increasing rates of obesity in childhood. The pathophysiology of type 2 DM discussed in this article focuses on the delicate balance between insulin sensitivity and insulin secretion. The risk factors for youth-onset type 2 DM are presented, with careful evaluation of their impact on insulin sensitivity versus insulin secretion.
Keywords: acanthosis nigricans; hyperinsulinemia; insulin resistance; obesity; polycystic ovary syndrome; type 2 diabetes mellitus
Published Online: 2014-07-22
Published in Print: 2000-12-01
© 2014 by Walter de Gruyter Berlin/Boston
