Abstract
Objectives
Given high and growing prevalence rate of urolithiasis in most societies as well as the problems caused by this issue, it is necessary to apply more cost-effective and safer therapeutic methods, which are accessible for all the individuals worldwide. Therefore, this study aimed to investigate efficacy of herbal medicines named Cynodon dactylon and Dolichos biflorus on solving and excretion of renal and urinary tract stones in patients with urolithiasis.
Methods
This study included 96 patients with urolithiasis who were randomly allocated into three groups. The first group received the extract of D. biflorus seeds (1,600 mg), the second group received extract of C. dactylon rhizome (1,600 mg) and the third group received placebo for 21 days. In this study, we used an hydroalcoholic extract of D. biflorus and C. dactylon prepared by Soxhlet method. For each patient, the size of the stones, the amount of calcium in the urine, the number of stones excreted and their chemical substance type were measured.
Results
In this study, changes were observed at the significance level in the interventions groups of 1 and 2, and the placebo group in the left kidney, so that changes in size of the stone in left kidney as intergroup were significantly different in these three groups (p=0.02). The mean of changes in stone size in left kidney in the group C. dactylon was 3.78 ± 7.1 and in the group D. biflorus, it was 0.27 ± 0.6.
Conclusions
A significant difference in the results of this study show that C. dactylon rhizome and D. biflorus seed extracts are able to decrease the size of the stone and can be effective on kidney stones excretion.
Funding source: Mashhad University of Medical Sciences
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Research funding: This study was supported by School of Persian and complementary medicine and Mashhad University of Medical Sciences Research Council. This paper is part of PhD thesis of Mohammad Azad Manjiri (Ph.D student of Persian Medicine). We highly appreciate Deputy Director of Research at Mashhad University of Medical Sciences and the valuable assistance of the colleagues of Imam Reza Hospital in Mashhad and all the patients who referred. The research budget of this study has been paid by Mashhad University of Medical Sciences.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors confirm that there are no conflicts of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The study was approved by the Ethics Committee of Mashhad University of Medical Sciences with IR.MUMS.REC.1397.325 verification code. It was also registered at the Iranian Center for Clinical Trials(IRCT) with IRCT20190410043235N1verification code.
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