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Licensed Unlicensed Requires Authentication Published by De Gruyter April 15, 2022

The biological activity and application of Monascus pigments: a mini review

  • Shan-Shan Feng , Wen Li ORCID logo EMAIL logo , Yong-Jun Hu , Jian-Xiang Feng EMAIL logo and Jing Deng ORCID logo EMAIL logo

Abstract

Monascus pigments (MPs), as secondary metabolites of Monascus, are microbial pigments which have been used for thousands of years. MPs are widely used in food industry as food pigments and preservatives, which have the stability of light resistance, high temperature resistance and acid-base change resistance. In addition, the antioxidant, antibacterial, antiviral and anti-tumor biological activities of MPs have also attracted people’s attention. Moreover, Due to the presence of citrinin, the safety of MPs still needs to be discussed and explored. In this paper, the production, biological activity, application in various fields and methods of detection and reduction of citrinin of MPs were reviewed, which provide new insights into the study and safe application related to human different diseases, medicines or health care products with MPs as active substances.


Corresponding authors: Wen Li, Hunan Province Key Laboratory of Edible Forestry Resources Safety and Processing Utilization, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China, E-mail: . Jian-Xiang Feng, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China, E-mail: ; and Jing Deng, Hunan Province Key Laboratory of Edible Forestry Resources Safety and Processing Utilization, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China, E-mail:
Shan-Shan Feng and Wen Li contributed equally to the work.

Funding source: Scientific Research Fund of Hunan Provincial Education Department

Award Identifier / Grant number: 21A0161

Funding source: National Key R&D Program of China

Award Identifier / Grant number: 2018YFE0110200

Funding source: Hunan Provincial Department of science and technology

Award Identifier / Grant number: 2019NK2111

Award Identifier / Grant number: 2020WK2020

Funding source: Scientific Research Projects of Hunan Provincial Health Commission

Award Identifier / Grant number: B2019062

Funding source: Central South University of Forestry and Technology Introduced Talent Research Startup Fund

Award Identifier / Grant number: 2021YJ014

Award Identifier / Grant number: 2021YJ034

Funding source: Natural Science Foundation of Hunan Province of China

Award Identifier / Grant number: 2019JJ80080

Award Identifier / Grant number: 2020JJ4278

Funding source: Program for Science & Technology Innovation Platform/Talents of Hunan Province

Award Identifier / Grant number: 2019TP1029

  1. Author contributions: Jing Deng put forward the idea of the article; Wen Li and Shan-Shan Feng writed the first draft; Jing Deng and Jian-Xiang Feng checked the paper and give suggestions for revision; Yong-Jun Hu thoroughly checked the paper and revise it. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

  2. Research funding: National Key R&D Program of China (2018YFE0110200), the key program of Hunan Provincial Department of science and technology (2020WK2020 and 2019NK2111), Natural Science Foundation of Hunan Province of China (2020JJ4278 and 2019JJ80080), Scientific Research Fund of Hunan Provincial Education Department (21A0161), Central South University of Forestry and Technology Introduced Talent Research Startup Fund (2021YJ034 and 2021YJ014), Program for Science & Technology Innovation Platform/Talents of Hunan Province (2019TP1029),Scientific Research Projects of Hunan Provincial Health Commission (B2019062).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

  4. Consent for publication: The work has not been published in other places or considered for publication in any other place, and its publication has been approved by all contributors.

References

1.. Patakova, P. Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol 2013;40:169–81. https://doi.org/10.1007/s10295-012-1216-8.Search in Google Scholar

2. Vendruscolo, F, Meinicke Bühler, RM, Cesar de Carvalho, J, de Oliveira, D, Moritz, DE, Schmidell, W, et al.. Monascus : a reality on the production and application of microbial pigments. Appl Biochem Biotechnol 2016;178:211–23. https://doi.org/10.1007/s12010-015-1880-z.Search in Google Scholar

3. Kim, D, Ku, S. Beneficial effects of Monascus sp. KCCM 10093 pigments and derivatives: a mini review. Molecules 2018;23:1–15. https://doi.org/10.3390/molecules23010098.Search in Google Scholar

4. Choe, D, Song, SM, Shin, CS, Johnston1, TV, Ahn, HJ, Kim, D, et al.. Production and characterization of anti-inflammatory Monascus pigment derivatives. Foods 2020c;9:858. https://doi.org/10.3390/foods9070858.Search in Google Scholar

5. Chen, W, Chen, R, Liu, Q, He, Y, He, K, Ding, X, et al.. Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi. Chem Sci 2017;8:4917–25. https://doi.org/10.1039/c7sc00475c.Search in Google Scholar

6. Babitha, S, Soccol, CR, Pandey, A. Solid-state fermentation for the production of Monascus pigments from jackfruit seed. Bioresour Technol 2007;98:1554–60. https://doi.org/10.1016/j.biortech.2006.06.005.Search in Google Scholar

7. Haque, MA, Kachrimanidou, V, Koutinas, A, Lin, CSK. Valorization of bakery waste for biocolorant and enzyme production by Monascus purpureus. J Biotechnol 2016;231:55–64. https://doi.org/10.1016/j.jbiotec.2016.05.003.Search in Google Scholar

8. Sehrawat, R, Kumar, S, Bashir, K, Kumar, SP, Swer, TL, Kumar, A. Bioutilization of agro-industrial waste to produce biopigment using Monascus purpureus MTCC 369 by solid state fermentation. Indian J Ecol 2016;41:128–33.Search in Google Scholar

9. Srianta, I, Harijono. Monascus-fermented sorghum: pigments and monacolin K produced by Monascus purpureus on whole grain, dehulled grain and bran substrates. Int Food Res J 2015;22:377–82.Search in Google Scholar

10. Srianta, I, Novita, Y, Kusumawati, N. Production of Monascus pigments on durian seed : effect of supplementation of carbon source. J Pure Appl Microbiol 2012;6:59–63.Search in Google Scholar

11. Srianta, I, Zubaidah, E, Estiasih, T, Yamada, M, Harijono. Comparison of Monascus purpureus growth, pigment production and composition on different cereal substrates with solid state fermentation. Biocatal Agric Biotechnol 2016;7:181–6. https://doi.org/10.1016/j.bcab.2016.05.011.Search in Google Scholar

12. Palma, C, Lloret, L, Sepúlveda, L, Contreras, E. Production of versatile peroxidase from Pleurotus eryngii by solid-state fermentation using agricultural residues and evaluation of its catalytic properties. Prep Biochem Biotechnol 2016;46:200–7. https://doi.org/10.1080/10826068.2015.1084513.Search in Google Scholar

13. Sadh, PK, Duhan, S, Duhan, JS. Agro-industrial wastes and their utilization using solid state fermentation: a review. Bioresour Bioprocess 2018;5:1. https://doi.org/10.1186/s40643-017-0187-z.Search in Google Scholar

14. Stloukal, R, Rosenberg, M, Rebroš, M, Dolejš, I, Krasn, V. Butanol production by immobilised Clostridium acetobutylicum in repeated batch, fed-batch, and continuous modes of fermentation. Bioresour Technol 2014;169:723–30. https://doi.org/10.1016/j.biortech.2014.07.039.Search in Google Scholar

15. Jones, SW, Fast, AG, Carlson, ED, Wiedel, CA, Au, J, Antoniewicz, MR, et al.. CO(2) fixation by anaerobic non-photosynthetic mixotrophy for improved carbon conversion. Nat Commun 2016;7:12800. https://doi.org/10.1038/ncomms12800.Search in Google Scholar

16. Sun, L, Wang, D-M, Sun, W-J, Cui, F-J, Gong, J-S, Zhang, X-M, et al.. Two-stage semi-continuous 2-keto-gluconic acid (2KGA) production by Pseudomonas plecoglossicida JUIM01 from rice starch hydrolyzate. Front Bioeng Biotechnol 2020;8:120. https://doi.org/10.3389/fbioe.2020.00120.Search in Google Scholar

17. Chen, G, Tang, R, Tian, X, Qin, P, Wu, Z. Change of Monascus pigment metabolism and secretion in different extractive fermentation process. Bioproc Biosyst Eng 2017;40:857–66. https://doi.org/10.1007/s00449-017-1750-x.Search in Google Scholar

18. Liu, J, Du, Y, Ma, H, Pei, X, Li, M. Enhancement of Monascus yellow pigments production by activating the cAMP signalling pathway in Monascus purpureus HJ11. Microb Cell Factories 2020;19:11. https://doi.org/10.1186/s12934-020-01486-y.Search in Google Scholar

19. Chen, G, Shi, K, Song, D, Quan, L, Wu, Z. The pigment characteristics and productivity shifting in high cell density culture of Monascus anka mycelia. BMC Biotechnol 2015;15:1–9. https://doi.org/10.1186/s12896-015-0183-3.Search in Google Scholar

20. Hajjaj, H, Goma, G, Franc, JM. Original article Effect of the cultivation mode on red pigments production from Monascus ruber. Int J Food Sci Technol 2015;50:1731–6. https://doi.org/10.1111/ijfs.12803.Search in Google Scholar

21. Tian, X, Tang, R, Chen, G, Zhang, F, Wu, Z. Separation of Monascus pigments from extractive fermentation broth with a high concentration of triton X-100. Separ Sci Technol 2018;53:2601–11. https://doi.org/10.1080/01496395.2018.1461906.Search in Google Scholar

22. Liu, J, Guo, T, Luo, Y, Chai, X, Wu, J, Zhao, W, et al.. Enhancement of Monascus pigment productivity via a simultaneous fermentation process and separation system using immobilized-cell fermentation. Bioresour Technol 2019;272:552–60. https://doi.org/10.1016/j.biortech.2018.10.072.Search in Google Scholar

23. Chen, G, Wang, M, Tian, X, Wu, Z. Analyses of Monascus pigment secretion and cellular morphology in non-ionic surfactant micelle aqueous solution. Microb Biotechnol 2018;11:409–19. https://doi.org/10.1111/1751-7915.13038.Search in Google Scholar

24. Lu, P, Wu, A, Zhang, S, Bai, J, Guo, T, Lin, Q, et al.. Triton X-100 supplementation regulates growth and secondary metabolite biosynthesis during in-depth extractive fermentation of Monascus purpureus. J Biotechnol 2021;341:137–45. https://doi.org/10.1016/j.jbiotec.2021.09.018.Search in Google Scholar

25. Lv, J, Qian, G-F, Chen, L, Liu, H, Xu, H-X, Xu, G-R, et al.. Efficient biosynthesis of natural yellow pigments by Monascus purpureus in a novel integrated fermentation system. J Agric Food Chem 2018;66:918–25. https://doi.org/10.1021/acs.jafc.7b05783.Search in Google Scholar

26. Huang, J, Guan, H-W, Huang, Y-Y, Lai, K-S, Chen, H-Y, Xue, H, et al.. Evaluating the effects of microparticle addition on mycelial morphology, natural yellow pigments productivity, and key genes regulation in submerged fermentation of Monascus purpureus. Biotechnol Bioeng 2021;118:2503–13. https://doi.org/10.1002/bit.27762.Search in Google Scholar

27. Huang, Z, Yang, S, Liu, H, Tian, X, Wu, Z. Sodium starch octenyl succinate facilitated the production of water-soluble yellow pigments in Monascus ruber fermentation. Appl Microbiol Biotechnol 2021;105:6691–706. https://doi.org/10.1007/s00253-021-11512-7.Search in Google Scholar

28. Fenice, M, Federici, F, Selbmann, L, Petruccioli, M. Repeated-batch production of pigments by immobilised Monascus purpureus. J Biotechnol 2000;80:271–6. https://doi.org/10.1016/S0168-1656(00)00271-6.Search in Google Scholar

29. Agboyibor, C, Kong, WB, Chen, D, Zhang, AM, Niu, SQ. Monascus pigments production, composition, bioactivity and its application: a review. Biocatal Agric Biotechnol 2018;16:433–47. https://doi.org/10.1016/j.bcab.2018.09.012.Search in Google Scholar

30. He, J, Jia, M, Li, W, Deng, J, Ren, J, Luo, F, et al.. Toward improvements for enhancement the productivity and color value of Monascus pigments : a critical review with recent updates. Crit Rev Food Sci Nutr 2021:1–15. https://doi.org/10.1080/10408398.2021.1935443.Search in Google Scholar

31. Terán Hilares, R, de Souza, RA, Marcelino, PF, da Silva, SS, Dragone, G, Mussatto, SI, et al.. Sugarcane bagasse hydrolysate as a potential feedstock for red pigment production by Monascus ruber. Food Chem 2018;245:786–91. https://doi.org/10.1016/j.foodchem.2017.11.111.Search in Google Scholar

32. Mahmoud, GAE, Soltan, HAH, Abdel-Aleem, WM, Osman, SAM. Safe natural bio-pigment production by Monascus purpureus using mixed carbon sources with cytotoxicity evaluation on root tips of Allium cepa L. J Food Sci Technol 2020:1–12. https://doi.org/10.1007/s13197-020-04758-y.Search in Google Scholar

33. Zhang, X, Wang, J, Chen, M, Wang, C. Effect of nitrogen sources on production and photostability of Monascus pigments in liquid fermentation. IERI Procedia 2013;5:344–50. https://doi.org/10.1016/j.ieri.2013.11.114.Search in Google Scholar

34. Tallapragada, P. Comparative study of Monascus sanguineus and Monascus purpureus for red pigment production under stress condition for red pigment production under stress condition. Int Food Res J 2013;20:1235–8.Search in Google Scholar

35. Ahn, J, Jung, J, Hyung, W, Haam, S, Shin, C. Enhancement of Monascus pigment production by the culture of Monascus sp. J101 at low temperature. Biotechnol Prog 2006;22:338–40. https://doi.org/10.1021/bp050275o.Search in Google Scholar

36. Shi, K, Song, D, Chen, G, Pistolozzi, M, Wu, Z, Quan, L. Controlling composition and color characteristics of Monascus pigments by pH and nitrogen sources in submerged fermentation. J Biosci Bioeng 2015;120:145–54. https://doi.org/10.1016/j.jbiosc.2015.01.001.Search in Google Scholar

37. Huang, J, Liao, N, Li, H. International Journal of Biological Macromolecules Linoleic acid enhance the production of moncolin K and red pigments in Monascus ruber by activating mokH and mokA , and by accelerating cAMP-PkA pathway. Int J Biol Macromol 2018;109:950–4. https://doi.org/10.1016/j.ijbiomac.2017.11.074.Search in Google Scholar

38. Qian, G, Huang, J, Farhadi, A, Zhang, B. Ethanol addition elevates cell respiratory activity and causes overproduction of natural yellow pigments in submerged fermentation of Monascus purpureus. LWT 2020:110534. https://doi.org/10.1016/j.lwt.2020.110534.Search in Google Scholar

39. Choe, D, Jang, H, Ho, H, Soo, C, Johnston, T, Kim, D, et al.. In vivo anti-obesity effects of Monascus pigment threonine derivative with enhanced hydrophilicity. J Funct Foods 2020a;67:103849. https://doi.org/10.1016/j.jff.2020.103849.Search in Google Scholar

40. Zhou, W, Guo, R, Guo, W, Hong, J, Li, L, Ni, L, et al.. Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet. Food Funct 2019;10:1073–84. https://doi.org/10.1039/c8fo02192a.Search in Google Scholar

41. Hsu, WH, Chen, TH, Lee, BH, Hsu, YW, Pan, TM. Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem Toxicol 2014;64:94–103. https://doi.org/10.1016/j.fct.2013.11.015.Search in Google Scholar

42. Lee, CL, Wen, JY, Hsu, YW, Pan, TM. Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. J Agric Food Chem 2013b;61:1493–500. https://doi.org/10.1021/jf304015z.Search in Google Scholar

43. Cimaglia, P, Vieceli Dalla Sega, F, Vitali, F, Lodolini, V, Bernucci, D, Passarini, G, et al.. Effectiveness of a novel nutraceutical compound containing red yeast rice, polymethoxyflavones and antioxidants in the modulation of cholesterol levels in subjects with hypercholesterolemia and low-moderate cardiovascular risk: the NIRVANA study. Front Physiol 2019;10:217. https://doi.org/10.3389/fphys.2019.00217.Search in Google Scholar

44. Lee, C, Wen, J, Hsu, Y, Pan, T. The blood lipid regulation of Monascus-produced monascin and ankaflavin via the suppression of low-density lipoprotein cholesterol assembly and stimulation of apolipoprotein A1 expression in liver. J Microbiol Immunol Infect 2018;51:27–37. https://doi.org/10.1016/j.jmii.2016.06.003.Search in Google Scholar

45. Kim, JH, Kim, HJ, Park, HW, Youn, SH, Choi, DY, Shin, CS. Development of inhibitors against lipase and α-glucosidase from derivatives of Monascus pigment. FEMS Microbiol Lett 2007;276:93–8. https://doi.org/10.1111/j.1574-6968.2007.00917.x.Search in Google Scholar

46. Fang, YX, Song, HP, Liang, JX, Li, P, Yang, H. Rapid screening of pancreatic lipase inhibitors from: Monascus-fermented rice by ultrafiltration liquid chromatography-mass spectrometry. Anal Methods 2017;9:3422–9. https://doi.org/10.1039/c7ay00777a.Search in Google Scholar

47. Wong, H-C, Bau, Y-S. Pigmentation and antibacterial activity of fast neutron- and X-ray-induced strains of Monascus purpureus went. Plant Physiol 1977;60:578–81. https://doi.org/10.1104/pp.60.4.578.Search in Google Scholar

48. Gao, X, Lu, X, Wang, Z, Liu, G, Li, X. Study on the extraction and antibacterial activity of Monascin. E3S Web Conf 2021;251:1–5. https://doi.org/10.1051/e3sconf/202125102061.Search in Google Scholar

49. de Oliveira Filho, JWG, Islam, MT, Ali, ES, Uddin, SJ, Santos, JVO, de Alencar, MVOB, et al.. A comprehensive review on biological properties of citrinin. Food Chem Toxicol 2017;110:130–41. https://doi.org/10.1016/j.fct.2017.10.002.Search in Google Scholar

50. Feng, LH, Li, YQ, Sum, GJ, Zhao, XZ. Antibacterial effect of orange Monascus pigment against Staphylococcus aureus. Acta Aliment 2019;48:169–76. https://doi.org/10.1556/066.2019.48.2.4.Search in Google Scholar

51. Zhao, G, Li, Y, Yang, J, Cui, K. Antibacterial characteristics of orange pigment extracted from Monascus pigments against Escherichia coli. Czech J Food Sci 2016;34:197–203. https://doi.org/10.17221/430/2015-CJFS.Search in Google Scholar

52. Kim, C, Jung, H, Kim, YO, Shin, CS. Antimicrobial activities of amino acid derivatives of Monascus pigments. FEMS Microbiol Lett 2006;264:117–24. https://doi.org/10.1111/j.1574-6968.2006.00451.x.Search in Google Scholar

53. Ding, F, Hu, B, Lan, S, Wang, H. Flexographic and screen printing of carboxymethyl chitosan based edible inks for food packaging applications. Food Packag Shelf Life 2020;26:100559. https://doi.org/10.1016/j.fpsl.2020.100559.Search in Google Scholar

54. Muharni, S, Almahdy, A, Martini, RD. Effect of the use of supplements PSIDII folium extract (Psidium guajava linn.) and red fermented rice (Monascus purpureus) in increase of thrombocytes at Dengue Hemorrhagic Fever (DHF) science in the installation of disease in hospital dr. M. Djamil Padan. Penelit Farm Indones 2013;1:57–61. https://doi.org/https://ejournal.unri.ac.id/index.php/FPFI/article/vie w/1247.Search in Google Scholar

55. Sun, J, Kim, S, Kim, G, Rhee, J, Kim, ND, Jung, H, et al.. Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway. J Antimicrob Chemother 2012;67:49–58. https://doi.org/10.1093/jac/dkr432.Search in Google Scholar

56. Sethi, G, Shanmugam, MK, Ramachandran, L, Kumar, AP, Tergaonkar, V. Multifaceted link between cancer and inflammation. Biosci Rep 2012;32:1–15. https://doi.org/10.1042/BSR20100136.Search in Google Scholar

57. Yasukawa, K, Takahashi, M, Natori, S, Kawai, K, Yamazaki, M, Takwuchi, M, et al.. Azaphilones inhibit tumor promotion by 12-O-Tetradecanoylphorbol-13-Acetate in two-stage carcinogenesis in mice. Oncology 1994;51:108–12. https://doi.org/10.1159/000227320.Search in Google Scholar

58. Hsu, L, Liang, Y, Hsu, Y, Kuo, Y, Pan, T. Anti-inflammatory properties of yellow and orange pigments from Monascus purpureus NTU 568. J Agric Food Chem 2013c;61:2796–802. https://doi.org/10.1021/jf305521v.Search in Google Scholar

59. Huang, YP, Li, P, Du, T, Du, XJ, Wang, S. Protective effect and mechanism of Monascus-fermented red yeast rice against colitis caused by Salmonella enterica serotype typhimurium ATCC14028. Food Funct 2020;11:6363–75. https://doi.org/10.1039/d0fo01017k.Search in Google Scholar

60. Wu, H, Chen, J, Wu, M, Cheng, M, Chang, H. Phytochemistry Letters Identification of new pigments produced by the fermented rice of the fungus Monascus pilosus and their anti-inflammatory activity. Phytochem Lett 2020;40:181–7. https://doi.org/10.1016/j.phytol.2020.04.014.Search in Google Scholar

61. Choe, D, Jung, HH, Kim, D, Shin, CS, Johnston, TV, Ku, S. In vivo evaluation of the anti-obesity effects of combinations of Monascus pigment derivatives. RSC Adv 2020b;10:1456–62. https://doi.org/10.1039/c9ra08036h.Search in Google Scholar

62. Cheng, C, Pan, TM. Protective effect of Monascus-fermented red mold rice against alcoholic liver disease by attenuating oxidative stress and inflammatory response. J Agric Food Chem 2011;59:9950–7. https://doi.org/10.1021/jf202577t.Search in Google Scholar

63. Aniya, Y, Yokomakura, T, Yonamine, M, Shimada, K. Screening of antioxidant action of various molds and protection of Monascus anka against experimentally induced liver injuries of rats. Gen Pharmacol Vasc Syst 1999;32:225–31. https://doi.org/10.1016/S0306-3623(98)00183-9.Search in Google Scholar

64. Huang, Q, Zhang, H, Xue, D. Enhancement of antioxidant activity of Radix Puerariae and red yeast rice by mixed fermentation with Monascus purpureus. Food Chem 2017;226:89–94. https://doi.org/10.1016/j.foodchem.2017.01.021.Search in Google Scholar

65. Zeng, H, Jie, Q, Xin, Z, Dayong, X, Minghua, X, Feng, L, et al.. Optimization of submerged and solid state culture conditions for Monascus pigment production and characterization of its composition and antioxidant activity. Pigment Resin Technol 2019;48:108–18. https://doi.org/10.1108/PRT-05-2018-0046.Search in Google Scholar

66. Zhang, X, Liu, C, Tian, W, Zhang, H, Li, P, Wang, J, et al.. Theoretical and experimental investigation of the antioxidative activity of monascin. Food Funct 2020;11:5915–23. https://doi.org/10.1039/c9fo02410g.Search in Google Scholar

67. Aniya, Y, Ohtani, II, Higa, T, Miyagi, C, Gibo, H, Shimabukuro, M, et al.. Dimerumic acid as an antioxidant of the mold, Monascus anka. Free Radic Biol Med 2000;28:999–1004. https://doi.org/10.1016/S0891-5849(00)00188-X.Search in Google Scholar

68. Prager, GW, Braga, S, Bystricky, B, Qvortrup, C, Criscitiello, C, Esin, E, et al.. Global cancer control : responding to the growing burden , rising costs and inequalities in access. ESMO Open 2018;3:e000285. https://doi.org/10.1136/esmoopen-2017-000285.Search in Google Scholar

69. Akihisa, T, Tokuda, H, Ukiya, M, Kiyota, A, Yasukawa, K, Sakamoto, N, et al.. Anti-tumor-initiating effects of monascin, an Azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice). Chem Biodivers 2005;2:1305–9. https://doi.org/10.1002/cbdv.200590101.Search in Google Scholar

70. Hsu, W, Pan, T. Monascus purpureus-fermented products and oral cancer: a review. Appl Microbiol Biotechnol 2012;93:1831–42. https://doi.org/10.1007/s00253-012-3891-9.Search in Google Scholar

71. Hsu, WH, Lee, BH, Hsu, YW, Pan, TM. Inhibition of Th2 cytokine production in T cells by monascin via PPAR-γ activation. J Agric Food Chem 2013a;61:8126–33. https://doi.org/10.1021/jf402373z.Search in Google Scholar

72. Tan, H, Xing, Z, Chen, G, Tian, X. Evaluating antitumor and antioxidant activities of yellow Monascus pigments from Monascus ruber fermentation. Molecules 2018;23:3242. https://doi.org/10.3390/molecules23123242.Search in Google Scholar

73. Guan, X. Cancer metastases: challenges and opportunities. Acta Pharm Sin B 2015;5:402–18. https://doi.org/10.1016/j.apsb.2015.07.005.Search in Google Scholar

74. Simpson, CD, Anyiwe, K, Schimmer, AD. Anoikis resistance and tumor metastasis. Cancer Lett 2008;272:177–85. https://doi.org/10.1016/j.canlet.2008.05.029.Search in Google Scholar

75. Chen, K, Lin, J-A, Yao, H-Y, Hsu, A-C, Tai, Y, Ho, B. Monascin accelerates anoikis in circulating tumor cells and prevents breast cancer metastasis. Oncol Lett 2020;20:1. https://doi.org/10.3892/ol.2020.12029.Search in Google Scholar

76. Zheng, Y, Xin, Y, Shi, X, Guo, Y. Cytotoxicity of Monascus pigments and their derivatives to human cancer cells. J Agric Food Chem 2010;58:9523–8. https://doi.org/10.1021/jf102128t.Search in Google Scholar

77. Zheng, Y, Zhang, Y, Chen, D, Chen, H, Lin, L, Zheng, C, et al.. Monascus pigment rubropunctatin : a potential dual agent for cancer chemotherapy and phototherapy Monascus pigment rubropunctatin : a potential dual agent for cancer chemotherapy and phototherapy. J Agric Food Chem 2016;64:2541–8. https://doi.org/10.1021/acs.jafc.5b05343.Search in Google Scholar

78. Lee, CI, Lee, CL, Hwang, JF, Lee, YH, Wang, JJ. Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells. Appl Microbiol Biotechnol 2013;97:1269–78. https://doi.org/10.1007/s00253-012-4279-6.Search in Google Scholar

79. El-Far, SW, Helmy, MW, Khattab, SN, Bekhit, AA, Hussein, AA, Elzoghby, AO. Phytosomal bilayer-enveloped casein micelles for codelivery of Monascus yellow pigments and resveratrol to breast cancer. Nanomedicine 2018;13:481–99. https://doi.org/10.2217/nnm-2017-0301.Search in Google Scholar

80. Ho, BY, Pan, T-M. The monascus metabolite monacolin k reduces tumor progression and metastasis of lewis lung carcinoma cells. J Agric Food Chem 2009;57:8258–65. https://doi.org/10.1021/jf901619w.Search in Google Scholar

81. Guo, M, Cai, Y, He, C, Li, Z. Coupled modeling of lipid deposition, inflammatory response and intraplaque angiogenesis in atherosclerotic plaque. Ann Biomed Eng 2019;47:439–52. https://doi.org/10.1007/s10439-018-02173-1.Search in Google Scholar

82. Wei, W, Li, C, Wang, Y, Su, H, Zhu, J, Kritchevsky, D. Hypolipidemic and anti-atherogenic effects of long-term Cholestin (Monascus purpureus-fermented rice, red yeast rice) in cholesterol fed rabbits. J Nutr Biochem 2003;14:314–8. https://doi.org/10.1016/S0955-2863(03)00051-2.Search in Google Scholar

83. Dong, Y, Cheng, H, Liu, Y, Xue, M, Liang, H. Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoe−/− mice in association with improved inflammation and altered gut microbiota composition. Food Funct 2019;10:3880–9. https://doi.org/10.1039/c9fo00583h.Search in Google Scholar

84. Feng, SJ, Tang, ZH, Wang, Y, Tang, XY, Li, TH, Tang, W, et al.. Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease. Chin J Nat Med 2019;17:50–8. https://doi.org/10.1016/S1875-5364(19)30009-3.Search in Google Scholar

85. Lee, CL, Hung, YP, Hsu, YW, Pan, TM. Monascin and ankaflavin have more anti-atherosclerosis effect and less side effect involving increasing creatinine phosphokinase activity than monacolin K under the same dosages. J Agric Food Chem 2013a;61:143–50. https://doi.org/10.1021/jf304346r.Search in Google Scholar

86. Hsu, W, Lee, B, Chang, Y, Hsu, Y, Pan, T. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Toxicol Appl Pharmacol 2013d;272:842–51. https://doi.org/10.1016/j.taap.2013.07.004.Search in Google Scholar

87. Shi, Y, Liao, VH, Pan, T. Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. Free Radic Biol Med 2012;52:109–17. https://doi.org/10.1016/j.freeradbiomed.2011.09.034.Search in Google Scholar

88. Lee, BH, Hsu, WH, Liao, TH, Pan, TM. The Monascus metabolite monascin against TNF-α-induced insulin resistance via suppressing PPAR-γ phosphorylation in C2C12 myotubes. Food Chem Toxicol 2011;49:2609–17. https://doi.org/10.1016/j.fct.2011.07.005.Search in Google Scholar

89. Lu, K, Chen, S-H, Lin, Y-S, Wu, H-P, Chao, P-M. An antidiabetic nutraceutical combination of red yeast rice (Monascus purpureus), bitter gourd (Momordica charantia), and chromium alleviates dedifferentiation of pancreatic β cells in db/db mice. Food Sci Nutr 2020;8:6718–26. https://doi.org/10.1002/fsn3.1966.Search in Google Scholar

90. Rajasekaran, A, Kalaivani, M. Protective effect of Monascus fermented rice against STZ-induced diabetic oxidative stress in kidney of rats. J Food Sci Technol 2015;52:1434–43. https://doi.org/10.1007/s13197-013-1191-8.Search in Google Scholar

91. Mormone, E, George, J, Nieto, N. Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem Biol Interact 2011;193:225–31. https://doi.org/10.1016/j.cbi.2011.07.001.Search in Google Scholar

92. Hsu, WH, Lee, BH, Hsu, YW, Pan, TM. Peroxisome proliferator-activated receptor-γ activators monascin and rosiglitazone attenuate carboxymethyllysine-induced fibrosis in hepatic stellate cells through regulating the oxidative stress pathway but independent of the receptor for advanced glycat. J Agric Food Chem 2013b;61:6873–9. https://doi.org/10.1021/jf402082g.Search in Google Scholar

93. Cheng, C, Pan, T. Ankaflavin and monascin induce apoptosis in activated hepatic stellate cells through suppression of the Akt/NF-κB/p38 signaling pathway. J Agric Food Chem 2016;64:9326–34. https://doi.org/10.1021/acs.jafc.6b03700.Search in Google Scholar

94. Wang, J, Wang, G, Yi, J, Xu, Y, Duan, S, Li, T, et al.. The effect of monascin on hematoma clearance and edema after intracerebral hemorrhage in rats. Brain Res Bull 2017;134:24–9. https://doi.org/10.1016/j.brainresbull.2017.06.018.Search in Google Scholar

95. Zheng, G, Zhan, Y, Tang, Q, Chen, T, Zheng, F, Wang, H, et al.. Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis. Food Funct 2018;9:1454–64. https://doi.org/10.1039/c7fo01892d.Search in Google Scholar

96. Tseng, WT, Hsu, YW, Pan, TM. The ameliorative effect of Monascus purpureus NTU 568-fermented rice extracts on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells and the rat model of Parkinson’s disease. Food Funct 2016;7:752–62. https://doi.org/10.1039/c5fo00976f.Search in Google Scholar

97. Yu, X, Wu, H, Zhang, J. Effect of Monascus as a nitrite substitute on color, lipid oxidation, and proteolysis of fermented meat mince. Food Sci Biotechnol 2015;24:575–81. https://doi.org/10.1007/s10068-015-0075-2.Search in Google Scholar

98. Cantwell, M, Elliott, C. Nitrates, nitrites and nitrosamines from processed meat intake and colorectal cancer risk. J Clin Nutr Diet 2017;03:27–30. https://doi.org/10.4172/2472-1921.100062.Search in Google Scholar

99. Abdel-Raheam, HEF, Abdel-Mageed, WS, Abd El-Rahman, MAM. Optimization of production of Monascus ruber pigments on broth medium and their application in flavored yogurts. Egypt J Food Sci 2019;47:271–83. https://doi.org/10.21608/EJFS.2019.19654.1030.Search in Google Scholar

100. Park, KH, Liu, Z, Park, CS, Ni, L. Microbiota associated with the starter cultures and brewing process of traditional Hong Qu glutinous rice wine. Food Sci Biotechnol 2016;25:649–58. https://doi.org/10.1007/s10068-016-0115-6.Search in Google Scholar

101. Karimi, S, Soofiani, NM, Lundh, T, Mahboubi, A. Evaluation of filamentous fungal biomass cultivated on vinasse as an alternative nutrient source of fish feed : protein , lipid , and mineral composition. Fermentation 2019;5:99. https://doi.org/10.3390/fermentation5040099.Search in Google Scholar

102. Manan, MA, Samat, N, Kasran, M, Hassan, H. Proximate and amino acids composition of Monascus fermented products with potential as functional feed ingredients. Cogent Food Agric 2017;3:1295767. https://doi.org/10.1080/23311932.2017.1295767.Search in Google Scholar

103. Yudiarti, T, Sugiharto, S, Isroli, I, Widiastuti, E, Wahyuni, HI, Sartono, TA. Effect of fermentation using Chrysonillia crassa and Monascus purpureus on nutritional quality , antioxidant , and antimicrobial activities of used rice as a poultry feed ingredient. J Adv Vet Anim Res 2019;6:168–73. https://doi.org/10.5455/javar.2019.f328.Search in Google Scholar

104. Sugiharto, S, Turrini, Y, Istoli, I, Endang, W, Wahyuni, HI, Tri, AS. Fermented feed as a potential source of natural antioxidants for broiler chickens – a mini review. Agric Conspectus Sci 2019;84:313–8.Search in Google Scholar

105. Wang, J-J, Pan, T-M, Shieh, M-J, Hsu, C. Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken. Appl Microbiol Biotechnol 2006;71:812–8. https://doi.org/10.1007/s00253-005-0222-4.Search in Google Scholar

106. Nuraini, S, Latif, SA. Fermented product by Monascus purpureus in poultry diet: effects on laying performance and egg quality. Pakistan J Nutr 2012;11:507. https://doi.org/10.3923/pjn.2013.886.888.Search in Google Scholar

107. Wang, P, Chen, S, Wei, C, Yan, Q, Sun, Y-Z, Yi, G, et al.. Monascus purpureus M-32 improves growth performance, immune response, intestinal morphology, microbiota and disease resistance in Litopenaeus vannamei. Aquaculture 2021;530:735947. https://doi.org/10.1016/j.aquaculture.2020.735947.Search in Google Scholar

108. Bhatia, D, Sharma, NR, Singh, J, Kanwar, RS. Biological methods for textile dye removal from wastewater: a review. Crit Rev Environ Sci Technol 2017;47:1836–76. https://doi.org/10.1080/10643389.2017.1393263.Search in Google Scholar

109. Yang, M, Yu, Y, Zhai, H, Sheng, J, Xing, T, Chen, G. Ecological dyeing of silk fabric with Monascus. J Textil Inst 2018;109:1329–34. https://doi.org/10.1080/00405000.2018.1423932.Search in Google Scholar

110. De Santis, D, Moresi, M, Gallo, AM, Petruccioli, M. Assessment of the dyeing properties of pigments from Monascus purpureus. J Chem Technol Biotechnol 2005;80:1072–9. https://doi.org/10.1002/jctb.1285.Search in Google Scholar

111. Velmurugan, P, Kamala-Kannan, S, Balachandar, V, Lakshmanaperumalsamy, P, Chae, JC, Oh, BT. Natural pigment extraction from five filamentous fungi for industrial applications and dyeing of leather. Carbohydr Polym 2010;79:262–8. https://doi.org/10.1016/j.carbpol.2009.07.058.Search in Google Scholar

112. Mondal, S, Pandit, SG, Puttananjaiah, MH, Harohally, NV, Dhale, MA. Structural and functional characterization of new pigment molecule Monashin from Monascus purpureus CFR410-11. Process Biochem 2019;82:173–8. https://doi.org/10.1016/j.procbio.2019.04.004.Search in Google Scholar

113. Thiagarajan, P, Nalankilli, G. Improving light fastness of reactive dyed cotton fabric with antioxidant and UV absorbers. Indian J Fiber Textil Res 2013;38:161–4.Search in Google Scholar

114. Velmurugan, P, Chae, JC, Lakshmanaperumalsamy, P, Yun, BS, Lee, KJ, Oh, BT. Assessment of the dyeing properties of pigments from five fungi and anti-bacterial activity of dyed cotton fabric and leather. Color Technol 2009;125:334–41. https://doi.org/10.1111/j.1478-4408.2009.00215.x.Search in Google Scholar

115. Ighodaro, OM, Akinloye, OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 2018;54:287–93. https://doi.org/10.1016/j.ajme.2017.09.001.Search in Google Scholar

116. Koli, SH, Suryawanshi, RK, Mohite, BV, Patil, SV. Prospective of Monascus pigments as an additive to commercial sunscreens. Nat Prod Commun 2019;14:1–7. https://doi.org/10.1177/1934578X19894095.Search in Google Scholar

117. Jin, Y, Pyo, Y. Effect of Monascus-fermented soybean extracts on antioxidant and skin aging-related enzymes inhibitory activities. Prev Nutr Food Sci 2017;22:376–80. https://doi.org/10.3746/pnf.2017.22.4.376.Search in Google Scholar

118. Martlnkovd, L, JQzlovB, P, Vesely, D. Biological activity of polyketide pigments produced by the fungus Monascus. J Appl Bacteriol 1995;79:609–16. https://doi.org/10.1111/j.1365-2672.1995.tb00944.x.Search in Google Scholar

119. Lin, CH, Lin, TH, Pan, TM. Alleviation of metabolic syndrome by monascin and ankaflavin: the perspective of Monascus functional foods. Food Funct 2017;8:2102–9. https://doi.org/10.1039/c7fo00406k.Search in Google Scholar

120. Zhang, H, Ahima, J, Yang, Q, Zhao, L, Zhang, X, Zheng, X. A review on citrinin: its occurrence, risk implications, analytical techniques, biosynthesis, physiochemical properties and control. Food Res Int 2021;141:110075. https://doi.org/10.1016/j.foodres.2020.110075.Search in Google Scholar

121. Ostry, V, Malir, F, Ruprich, J. Producers and important dietary sources of ochratoxin A and citrinin. Toxins 2013;5. https://doi.org/10.3390/toxins5091574.Search in Google Scholar

122. Huang, Y-L, Pan, W-L, Cai, W-W, Ju, J-Q, Sun, S-C. Exposure to citrinin induces DNA damage, autophagy, and mitochondria dysfunction during first cleavage of mouse embryos. Environ Toxicol 2021;36:2217–24. https://doi.org/10.1002/tox.23335.Search in Google Scholar

123. Sharath Babu, GR, Anand, T, Ilaiyaraja, N, Khanum, F, Gopalan, N. Pelargonidin modulates Keap1/Nrf2 pathway gene expression and ameliorates citrinin-induced oxidative stress in HepG2 cells. Front Pharmacol 2017;8:868. https://doi.org/10.3389/fphar.2017.00868.Search in Google Scholar

124. Li, Y, Wang, N, Jiao, X, Tu, Z, He, Q, Fu, J. The ctnF gene is involved in citrinin and pigment synthesis in Monascus aurantiacus. J Basic Microbiol 2020;60:873–81. https://doi.org/10.1002/jobm.202000059.Search in Google Scholar

125. Wang, L, Dai, Y, Chen, W, Shao, Y, Chen, F. Effects of light intensity and color on the biomass, extracellular red pigment, and citrinin production of Monascus ruber. J Agric Food Chem 2016;64:9506–14. https://doi.org/10.1021/acs.jafc.6b04056.Search in Google Scholar

126. Xu, Y, Ma, B, Chen, E, Yu, X, Ye, Z, Sun, C, et al.. Dual fluorescent immunochromatographic assay for simultaneous quantitative detection of citrinin and zearalenone in corn samples. Food Chem 2021;336:127713. https://doi.org/10.1016/j.foodchem.2020.127713.Search in Google Scholar

127. Hu, X, Liu, Y, Xia, Y, Zhao, F, Zeng, B. A novel ratiometric electrochemical sensor for the selective detection of citrinin based on molecularly imprinted poly(thionine) on ionic liquid decorated boron and nitrogen co-doped hierarchical porous carbon. Food Chem 2021;363:130385. https://doi.org/10.1016/j.foodchem.2021.130385.Search in Google Scholar

128. Zhang, M, Xue, X, Gong, H, Liu, B, Ye, L. Double isothermal amplification and CRISPR-Cas12a for sensitive detection of citrinin. ACS Food Sci Technol 2021;1:1997–2005. https://doi.org/10.1021/acsfoodscitech.1c00321.Search in Google Scholar

129. Kong, D, Xie, Z, Liu, L, Song, S, Kuang, H. Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of citrinin in cereals. Food Agric Immunol 2017;28:754–66. https://doi.org/10.1080/09540105.2017.1312293.Search in Google Scholar

130. Chen, Y-P, Tseng, C-P, Chien, I-L, Wang, W-Y, Liaw, L-L, Yuan, G-F. Exploring the distribution of citrinin biosynthesis related genes among Monascus species. J Agric Food Chem 2008;56:11767–72. https://doi.org/10.1021/jf802371b.Search in Google Scholar

131. Li, Y-P, Xu, Y, Huang, Z-B. Isolation and characterization of the citrinin biosynthetic gene cluster from Monascus aurantiacus. Biotechnol Lett 2012;34:131–6. https://doi.org/10.1007/s10529-011-0745-y.Search in Google Scholar

132. Li, Z, Liu, Y, Li, Y, Lin, F, Wu, L. Screening and identification of Monascus strains with high-yield monacolin K and undetectable citrinin by integration of HPLC analysis and pksCT and ctnA genes amplification. J Appl Microbiol 2020;129:1410–8. https://doi.org/10.1111/jam.14689.Search in Google Scholar

133. Ning, Z-Q, Cui, H, Xu, Y, Huang, Z-B, Tu, Z, Li, Y-P. Deleting the citrinin biosynthesis-related gene, ctnE, to greatly reduce citrinin production in Monascus aurantiacus Li AS3.4384. Int J Food Microbiol 2017;241:325–30. https://doi.org/10.1016/j.ijfoodmicro.2016.11.004.Search in Google Scholar

134. Chen, Y, Liu, Y, Zhang, J, Li, L, Wang, S, Gao, M. Lack of the histone methyltransferase gene Ash2 results in the loss of citrinin production in Monascus purpureus. J Food Protect 2020;83:702–9. https://doi.org/10.4315/0362-028X.JFP-19-407.Search in Google Scholar

135. Liang, B, Du, X-J, Li, P, Sun, C-C, Wang, S. Investigation of citrinin and pigment biosynthesis mechanisms in Monascus purpureus by transcriptomic analysis. Front Microbiol 2018;9.10.3389/fmicb.2018.01374Search in Google Scholar PubMed PubMed Central

136. Zheng, Y, Huang, Y, Mao, Z, Shao, Y. Histone deacetylase MrRpd3 plays a major regulational role in the mycotoxin production of Monascus ruber. Food Control 2022;132:108457. https://doi.org/10.1016/j.foodcont.2021.108457.Search in Google Scholar

137. Hong, JL, Wu, L, Lu, JQ, Zhou, WB, Cao, YJ, Lv, WL, et al.. Comparative transcriptomic analysis reveals the regulatory effects of inorganic nitrogen on the biosynthesis of: Monascus pigments and citrinin. RSC Adv 2020;10:5268–82. https://doi.org/10.1039/c9ra09760k.Search in Google Scholar

138. Zhen, Z, Xiong, X, Liu, Y, Zhang, J, Wang, S, Li, L, et al.. NaCl inhibits citrinin and stimulates Monascus pigments and monacolin K production. Toxins 2019;11. https://doi.org/10.3390/toxins11020118.Search in Google Scholar

139. Liu, H, Huang, Z, Yang, S, Tian, X, Wu, Z. Inducing red pigment and inhibiting citrinin production by adding lanthanum(III) ion in Monascus purpureus fermentation. Appl Microbiol Biotechnol 2021;105:1905–12. https://doi.org/10.1007/s00253-021-11162-9.Search in Google Scholar

140. Ouyang, W, Liu, X, Wang, Y, Huang, Z, Li, X. Addition of genistein to the fermentation process reduces citrinin production by Monascus via changes at the transcription level. Food Chem 2021;343:128410. https://doi.org/10.1016/j.foodchem.2020.128410.Search in Google Scholar

141. Schmidt-Heydt, M, Cramer, B, Graf, I, Lerch, S, Humpf, H-U, Geisen, R. Wavelength-dependent degradation of ochratoxin and citrinin by light in vitro and in vivo and its implications on Penicillium. Toxins 2012;4. https://doi.org/10.3390/toxins4121535.Search in Google Scholar

142. Kanpiengjai, A, Mahawan, R, Lumyong, S, Khanongnuch, C. A soil bacterium Rhizobium borbori and its potential for citrinin-degrading application. Ann Microbiol 2016;66:807–16. https://doi.org/10.1007/s13213-015-1167-1.Search in Google Scholar

143. Ahima, J, Zhang, H, Apaliya, MT, Zhang, X, Yang, Q, Zhao, L. The effect of Rhodotorula mucilaginosa on degradation of citrinin production by Penicillium digitatum and its toxin in vitro. J Food Meas Charact 2019;13:2998–3004. https://doi.org/10.1007/s11694-019-00220-6.Search in Google Scholar

144. Kraboun, K, Tochampa, W, Jittrepotch, N, Rojsuntornkitti, K, Chatdamrong, W, Kongbangkerd, T. Optimization of ultrasonic-assisted extraction for monacolin K, antioxidant activity, pigment and citrinin of monascal waxy corn by response surface methodology. Food Appl Biosci J 2017;5:115–31. https://doi.org/10.14456/fabj.2017.10.Search in Google Scholar

Received: 2021-08-07
Accepted: 2022-03-17
Published Online: 2022-04-15

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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