Abstract
The reaction of 4-amino-5-bromo-2-chloro-6-methylpyrimidine (1) with carbon disulfide in the presence of KOH in DMF quantitatively gave 5-chloro-7-methylthiazolo[4,5-d] pyrimidine-2 (3H)-thione (2) which was then alkylated at the sulfur atom with various alkyl halides in the presence of Et3N in acetonitrile to give alkylthio derivatives 3. The substitution of the chlorine atom in 3 with morpholine was also investigated. The synthesized compounds were subjected to antibacterial evaluations.
©2011 by Walter de Gruyter Berlin Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.