Abstract
Objectives
Ethno-botanical surveys uncovered the use of Datura stramonium in the management of mental health abnormalities. Antidepressant- and anxiolytic-like activities of hydroethanol leaf extract of D. stramonium (HLDS) in mice and its possible mechanism of action were investigated in this study.
Methods
The hole-board test (HBT), open field test (OFT), elevated plus maze test (EPMT), and social interaction test (SIT) were used to investigate the anxiolytic-like activity while forced swim test (FST) and tail suspension test (TST) were employed for the antidepressant effect. Mice were pre-treated orally with purified water (10 mL/kg), bromazepam (1 mg/kg), fluoxetine (20 mg/kg) and D. stramonium (25, 50, 100 and 200 mg/kg). One hour post-treatment, mice were subjected to the various tests.
Results
In HBT, D. stramonium increased the head dips and sectional crossings turnover. D. stramonium increased the number of square crossed and rearings/assisted rearings in OFT. DS increased the time spent in open arms of EPM. In SIT, D. stramonium increased the frequency/duration of interactions. In FST and TST, D. stramonium decreased the duration of immobility which were reversed by doxazosin (α1 adrenoceptor antagonist) and ondasentron (5-HT3 receptor antagonist).
Conclusions
HLDS has anxiolytic- and antidepressant-like activities through modulation of serotoninergic and adrenergic neurotransmissions.
Acknowledgments
The authors would like to appreciate the contributions of Dr Ishola of University of Lagos, Nigeria for his scientific advise. Authors also appreciate Mr Osipitan Luqman for his hard work.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission. All authors involved at every stage of this research work.
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Competing interests: There was no case of conflicting interests among authors).
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: Ethical approval was obtained from the Health Research Ethics Committee (HREC) of college of medicine, university of Lagos, Nigeria. The guidelines of National Institutes of Health (NIH) for the handling of Laboratory Animals were adhered to.
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