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Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome

  • Yulia A. Koloda ORCID logo , Yulia V. Denisova ORCID logo EMAIL logo and Natalia M. Podzolkova ORCID logo
Published/Copyright: December 1, 2021
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Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 37 Issue 2

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing, which is defined by the accumulation of multiple, small fluid-filled ovarian cysts without the selection of a single dominant follicle. Most PCOS phenotypes are characterized by the absence of spontaneous ovulation, resistance toward ovulation inductors, the production of a large immature oocytes number, and the high prevalence of ovarian hyperstimulation syndrome, resulting in reduced assisted reproductive technologies (ART) programs effectiveness. The review analyses current data about the relationship between polymorphism genotypes of KISS genes, follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and their receptors genes, gonadotropin-releasing hormone (GnRH), estrogen, and progesterone receptors genes, the PCOS risk and the features of ovarian response to stimulation during ART cycles. The use of single nucleotide polymorphisms (SNPs) as prognostic markers of ART programs outcomes would provide a personalized approach to the drugs and doses choice for ovarian stimulation and significantly increase the chance of pregnancy.

Keywords: ART programs; clinical pregnancy; genetic polymorphism; ovarian hyperstimulation syndrome; ovarian response; polycystic ovary syndrome
Corresponding author: Yulia V. Denisova, Resident at the Department of Obstetrics and Gynecology, Pediatric Faculty, FSBEI FPE “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation, Postal address: 2/1-1 Barrikadnaya str., Moscow 125993, Russian Federation, Phone: +7(495)680 05 99, Fax: +7(499)254 98 05, E-mail:

  1. Research funding: None declared.

  2. Author contributions: Study concept and drafting: Yulia Alekseevna Koloda; critical revision for imperative rational content: Yulia Alekseevna Koloda and Natalia Mikhailovna Podzolkova; editing: Yulia Alekseevna Koloda, and reference collected by Yulia Vadimovna Denisova. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Received: 2021-03-25
Accepted: 2021-08-31
Published Online: 2021-12-01

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Potentials of autophagy enhancing natural products in the treatment of Parkinson disease
  4. Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome
  5. Minireview
  6. Influence of GSTM1, GSTT1, and GSTP1 genetic polymorphisms on disorders in transplant patients: a systematic review
  7. Original Articles
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  11. CYP2C19*2 genetic polymorphism and incidence of in-stent restenosis in patients on clopidogrel: a matched case-control study
  12. Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions
  13. Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
  14. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice
  15. Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents
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DOI:  doi.org/10.1515/dmpt-2021-0123
Keywords for this article
ART programs; clinical pregnancy; genetic polymorphism; ovarian hyperstimulation syndrome; ovarian response; polycystic ovary syndrome

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Potentials of autophagy enhancing natural products in the treatment of Parkinson disease
  4. Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome
  5. Minireview
  6. Influence of GSTM1, GSTT1, and GSTP1 genetic polymorphisms on disorders in transplant patients: a systematic review
  7. Original Articles
  8. Modifying effects of TNF-α, IL-6 and VDR genes on the development risk and the course of COVID-19. Pilot study
  9. Prevalence of ABCB1 3435C>T polymorphism in the Cuban population
  10. The association of cytochrome 7A1 and ATP-binding cassette G8 genotypes with type 2 diabetes among Jordanian patients
  11. CYP2C19*2 genetic polymorphism and incidence of in-stent restenosis in patients on clopidogrel: a matched case-control study
  12. Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions
  13. Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
  14. Cnestis ferruginea Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice
  15. Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents
  16. Short Communication
  17. Comparison of different autoanalyzers for the determination of lymphocyte and neutrophil counts in mouse blood
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