Functional Genomics in HIV-1 Virus Replication: Protein-Protein Interactions as a Basis for Recruiting the Host Cell Machinery for Viral Propagation

Taurai Tasara; Michael O. Hottiger; Ulrich Hübscher

doi:10.1515/BC.2001.125

Published by De Gruyter June 1, 2005

Functional Genomics in HIV-1 Virus Replication: Protein-Protein Interactions as a Basis for Recruiting the Host Cell Machinery for Viral Propagation

Taurai Tasara , Michael O. Hottiger and Ulrich Hübscher

From the journal Biological Chemistry

https://doi.org/10.1515/BC.2001.125

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Abstract

Identification and characterization of proteinprotein interactions between the host cell and parasites both enhance our understanding of basic cell biology and provide insights into central processes of parasite life cycles. Research on HIV-1 has broadened our knowledge of the various molecular events involved. However, our understanding of how this virus interacts with the host cell at the level of proteinprotein interaction is still limited. Through these interactions the virus is able to recruit certain cellular metabolic pathways for its replication. Here we summarize our current knowledge of proteinprotein interactions between HIV-1 and host cell factors during viral replication.

Published Online: 2005-06-01

Published in Print: 2001-07-20

Functional Genomics in HIV-1 Virus Replication: Protein-Protein Interactions as a Basis for Recruiting the Host Cell Machinery for Viral Propagation

Abstract

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