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Licensed Unlicensed Requires Authentication Published by De Gruyter September 6, 2012

Identification of circulating microRNAs as biomarkers in cancers: what have we got?

  • Yu Sun , Kuo Zhang , Gaowei Fan and Jinming Li EMAIL logo

Abstract

During the past few years there has been great interest in the development of circulating microRNAs (miRNAs) as stable blood-based biomarkers for cancer detection. Deregulation of miRNAs in blood samples has shown considerable clinical utilities in cancers. Due to poorly characterized preanalytical and analytical variables and the lack of a standardized measurement protocol, the application of these miRNA fingerprints is hindered by conflicting results. In this review, we outline our current understanding of preanalytically and analytically confounding factors. We believe that great consideration should be taken in the development of circulating miRNA as tumor biomarkers.


Corresponding author: Jinming Li, National Center for Clinical Laboratories, Beijing Hospital, No. 1 Dahua Road, Dongdan, Beijing 100730, People’s Republic of China Phone: +86 10 58115053, Fax: +86 10 65212064

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Received: 2012-06-07
Accepted: 2012-08-03
Published Online: 2012-09-06
Published in Print: 2012-12-01

©2012 by Walter de Gruyter Berlin Boston

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