Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access April 14, 2016

Hemostatic, Resorbable Dressing of Natural Polymers-Hemoguard

  • Maria Wiśniewska-Wrona , Magdalena Kucharska , Marcin H. Struszczyk , Magdalena Cichecka , Bożena Wilbik-Hałgas , Maria Szymonowicz , Danuta Paluch , Krystyna Guzińska and Zbigniew Rybak
From the journal Autex Research Journal

Abstract

Investigations are presented for the preparation of a model hemostatic dressing that would exhibit an adequate hemostatic capacity in injuries and surgical wounds, an antibacterial activity to prevent primary and secondary infections, and offer safety in use. The Hemoguard dressing has been designed as a powder prepared from the complex chitosan/alginate Na/Ca in the form of micro- and nano-fibrids. Useful antibacterial and hemostatic properties of Hemoguard, which would qualify the material as first aid dressing and a temporary protection of injury wounds in field conditions, were assessed. Biocompatibility of the dressing was confirmed by biological in vitro examinations.

References

[1] Niekraszewicz A., Lebioda J., Kucharska M., Wesołowska E.; „Research into Developing Antibacterial Dressing Materials”, Fibres & Textiles in Eastern Europe, vol.15, No 1(60), (2007)Search in Google Scholar

[2] Kucharska M., Niekraszewicz A., Lebioda J., Brzoza-Malczewska K., Wesołowska E., „Bioactive Composite Materials” monograph, vol. XII edited by M. Jaworska „Progress on Chemistry and Application of Chitin and Its Derivatives”, p.131-138, Polish Chitin Society, (2007)Search in Google Scholar

[3] Niekraszewicz A., Kucharska M., Wawro D., Struszczyk M. H., Rogaczewska A.: “Development of a Manufacturing Method for Surgical Meshes Modified by Chitosan”, Fibres & Textiles in Eastern Europe, vol.15, No 3(62), (2007)Search in Google Scholar

[4] Niekraszewicz A., Kucharska M., Wiśniewska-Wrona M., Kardas I.: „Biological and Physicochemical Study of the Implantation of a Modified Polyester Vascular Prosthesis”, Fibres & Textiles in Eastern Europe, vol. 18, No 6 (83), p. 100-105, (2010)Search in Google Scholar

[5] Niekraszewicz A., Kucharska M., Kardas I., Wiśniewska-Wrona M., Kustosz R., Jarosz A.: „Chitosan Coatings to Seal Cardiovascular Prostheses”, Fibres & Textiles in Eastern Europe, vol. 19, No 3 (86), p. 106-111, (2011)Search in Google Scholar

[6] Kucharska M., Ciechańska D., Niekraszewicz A., Wiśniewska–Wrona M., Kardas I.: “Potential use of chitosan–based materials in medicine”, „Progress on chemistry and application of chitin and its derivatives”, periodical, vol. XV, ed by M. Jaworska, Polish Chitin Society, Łódź, p.169-176, (2010)Search in Google Scholar

[7] Wiśniewska-Wrona M., Kucharska M., Kardas I., Bodek A., Bodek K. H.: „ Polymer biocomposites used in bedsores treatment” „Progress on chemistry and application of chitin and its derivatives”, periodical, vol. XVI, ed. by M. Jaworska, Polish Chitin Society, Łódź, p.111-120, (2011)Search in Google Scholar

[8] Kucharska M., Niekraszewicz A., Kardas I., Marcol W., Właszczuk A., Larysz-Brysz M., Lewin – Kowalik J.: “Developing a Model of Peripheral Nerve Graft Based on Natural Polymers”, Fibres & Textiles in Eastern Europe, vol. 20, No 6B (96), p. 115-120, (2012)Search in Google Scholar

[9] Kucharska M., Struszczyk M. H., Cichecka M., Brzoza-Malczewska K., Wiśniewska-Wrona M.: “Prototypes of Primary Wound Dressing of fibrous and Quasi_fibrous Structure in Terms of Safety of Their Usage”, Fibres & Textiles in Eastern Europe, vol. 20, No 6B (96), p. 142-148, (2012)Search in Google Scholar

[10] Wiśniewska-Wrona M., Niekraszewicz A., Struszczyk H.,. Guzińska G; „Estimation of Polymer Compositions Containing Chitosan for Veterinary Applications”, Fibres & Textiles in Eastern Europe, vol.10, No 3(38), (2002)Search in Google Scholar

[11] PL 214 380 B1 (2008)Search in Google Scholar

[12] PL 214 380 B1 (2008)Search in Google Scholar

[13] PN-EN ISO 13726-1: 2005, Methods for the direct testing of wounds. Part 1: Aspects concerning absorption.Search in Google Scholar

[14] PN-EN ISO 13726-2:2005, Methods for the direct testing of wounds. Part 2: Transmission of moisture through the dressing with a semi-permeable film” for model dressing.Search in Google Scholar

[15] Procedure PB 1, Examination of antibacterial action of textile products. Quantitative test” prepared on base of JISL 1902:2002.Search in Google Scholar

[16] ASTM, F 756 – 00, 2008, Standard practice for assessment of hemolytic properties of materials.Search in Google Scholar

[17] PN EN ISO 10993-4: 2009, Biological evaluation of medical devices. Part 4: Selection of tests for interactions with blood.Search in Google Scholar

[18] Szymonowicz M., Fraczek-Szczypta A., Rybak Z., Blazewicz S.: „Comparative assessment of the effect of carbon-based material surfaces on blood clotting activation and haemolysis”. Diamond & Related Materials, 2013, Vol. 40, 89-95.10.1016/j.diamond.2013.10.002Search in Google Scholar

[19] Szymonowicz M., Pielka S., Owczarek A, Haznar D., Pluta J.: “Study on influence of gelatin-alginate matrixes on the coagulation system and morphotic blood elements.” Macromolecular Symposia, 2007, Vol. 253, 71-76.10.1002/masy.200750709Search in Google Scholar

[20] Gadelha de Carvalho M.M.S., Montenegro Stamford T. C., Pereira dos Santos E., Tenório and F.Sampaio P.: “Chitosan as an oral antimicrobial agent”, Formatex 2011Search in Google Scholar

[21] Yadav AV, Bhise .B.:” Chitosan: a potential biomaterial effective against typhoid.” Cur. Sci.87(9): 1176-1178, (2004)Search in Google Scholar

Published Online: 2016-4-14
Published in Print: 2016-3-1

© 2016 Autex Research Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 23.5.2024 from https://www.degruyter.com/document/doi/10.1515/aut-2015-0051/html
Scroll to top button