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United Kingdom Cystic Fibrosis Gene Therapy Consortium Multidose Trial

The Proposed Use of Computed Tomography

¹ Department of Radiology, Royal Brompton Hospital, London, United Kingdom

Correspondence and requests for reprints should be addressed to Zelena A. Aziz, Department of Radiology, The London Chest Hospital, Bonner Road, London E2 9JX, UK. E-mail: Tunku.Aziz{at}bartsandthelondon.nhs.uk

ABSTRACT

Interest in the role of computed tomography (CT) as a monitoring tool in cystic fibrosis (CF) research has gained momentum in the past 5 years. This is a consequence of the rapid development of therapeutic options for CF lung disease and hence the need for sensitive outcome measures that can be applied to clinical intervention trials. The following article summarizes the proposed use of CT in a forthcoming multidose gene therapy trial. Issues surrounding dose, timing of scans, scoring, and quantification of CT morphologic features are discussed. The literature which supports the use of CT as a surrogate outcome measure is also summarized.

Key Words: computed tomography • cystic fibrosis • outcome measure