Regular Article
Cytotoxic and Cytostatic Effects of Leaf Aqueous Extract of Crinum asiaticum in Allium cepa Root Apical Meristem Cells
2022 Volume 87 Issue 2 Pages 107-112
Details
2022 Volume 87 Issue 2 Pages 107-112
Crinum asiaticum is a well-known medicinal plant of the family Amaryllidaceae. The present study aimed to analyze the cytotoxic and cytostatic effects of leaf aqueous extract of C. asiaticum (LAECA). The 48-h aged Allium cepa roots were treated with LAECA (0.25–2.0 mg mL−1) and root growth inhibition, mitotic index (MI), chromosomal and cytological aberrations were analyzed. The LAECA induced a concentration-dependent root growth retardation, decreased MI, and increased the various cytological aberrations, like giant cells, hyperchromasia, sticky chromosome, chromosome break, polar deviation, and binucleated cells in A. cepa root apical meristem. Thus, the present study explores the cytotoxic and cytostatic effects of LAECA.
