Alternate Exon in the 5'-Untranslated Region of the Human ACTH Receptor Gene

MITSUMASA KUBO; CHIKARA SHIMIZU; HIROMICHI KIJIMA; TATSUYA ISHIZUKA; KAZUHIKO TAKANO; AKIKO TAKANO; TAKAO KOIKE

doi:10.1507/endocrj.47.543

MITSUMASA KUBO, CHIKARA SHIMIZU, HIROMICHI KIJIMA, TATSUYA ISHIZUKA, KAZUHIKO TAKANO, AKIKO TAKANO, TAKAO KOIKE

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Keywords: Gene structure, Alternative splicing, ACTH receptor, Adrenal gland, Human

JOURNAL FREE ACCESS

2000 Volume 47 Issue 5 Pages 543-548

DOI https://doi.org/10.1507/endocrj.47.543

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Abstract

The human ACTH receptor (ACTH-R) gene consists of two exons; the first encodes the 5'-untranslated region (UTR) and the second encodes part of the 5'-UTR, the entire coding region, and the whole of the 3'-UTR. While investigating the transcription initiation site of the human ACTH-R gene by 5'-rapid amplification of cDNA ends, we found a 157-bp alternate exon in the 5'-UTR. This newly identified exon was irrelevant to the alternate exon in the mouse ACTH-R gene which we reported previously.

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