CMAJ • April 25, 2006; 174 (9). doi:10.1503/cmaj.051299.
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Review

The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies

Magali Poulain, Mariève Doucet, Geneviève C. Major, Vicky Drapeau, Frédéric Sériès, Louis-Philippe Boulet, Angelo Tremblay and François Maltais

From the Division de kinésiologie, Département de médecine sociale et préventive (Poulain, Major, Drapeau, Tremblay) and Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie (Poulain, Doucet, Sériès, Boulet, Maltais), Université Laval, Québec, Qué.

Correspondence to: Dr. François Maltais, Centre de Pneumologie, Hôpital Laval, 2725 chemin Ste-Foy, Québec QC G1V 4G5; francois.maltais{at}med.ulaval.ca

Abstract

Sedentary lifestyles and increased pollution brought about by industrialization pose major challenges to the prevention of both obesity and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, obstructive sleep apnea and obesity hypoventilation syndrome. Obesity has emerged as an important risk factor for these respiratory diseases, and in many instances weight loss is associated with important symptomatic improvement. Moreover, obesity may influence the development and presentation of these diseases. In this article, we review the current understanding of the influence of obesity on chronic respiratory diseases and the clinical management of obesity concurrent with asthma, COPD, obstructive sleep apnea or obesity hypoventilation syndrome.




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