CMAJ • January 17, 2006; 174 (2). doi:10.1503/cmaj.050855.
© 2006 CMA Media Inc. or its licensors
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Review

The use of antidepressants to treat depression in children and adolescents

Amy H. Cheung, Graham J. Emslie and Taryn L. Mayes

From the Department of Psychiatry, University of Toronto, Toronto, Ont. (Cheung), and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex. (Emslie, Mayes)

Correspondence to: Dr. Amy H. Cheung, Health Systems Research and Consulting Unit, Centre for Addiction and Mental Health, 33 Russell St., 3rd Floor Tower, Toronto ON M5S 2S1; amy_cheung{at}camh.net

Abstract

The dramatic increase over the past 10 years in the amount of available clinical research on the use of antidepressants to treat major depression in children and adolescents has substantially improved our knowledge of the safety and efficacy of these medications in the pediatric population. Many questions remain, however, that highlight the need to continue research in this patient population rather than relying on the extrapolation of data from trials involving adults. In this article, we review the current state of research into antidepressant therapy for major depression in children and adolescents. In addition, we discuss methodologic issues and clinical implications specific to the pediatric population.




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